ID A0YWD5_LYNSP Unreviewed; 795 AA.
AC A0YWD5;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=L8106_21934 {ECO:0000313|EMBL:EAW34628.1};
OS Lyngbya sp. (strain PCC 8106) (Lyngbya aestuarii (strain CCY9616)).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Oscillatoriales; Oscillatoriaceae; Lyngbya.
OX NCBI_TaxID=313612 {ECO:0000313|EMBL:EAW34628.1, ECO:0000313|Proteomes:UP000000737};
RN [1] {ECO:0000313|EMBL:EAW34628.1, ECO:0000313|Proteomes:UP000000737}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PCC8106 {ECO:0000313|Proteomes:UP000000737};
RA Stal L., Ferriera S., Johnson J., Kravitz S., Halpern A., Remington K.,
RA Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAW34628.1}.
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DR EMBL; AAVU01000041; EAW34628.1; -; Genomic_DNA.
DR RefSeq; WP_009786778.1; NZ_AAVU01000041.1.
DR AlphaFoldDB; A0YWD5; -.
DR eggNOG; COG0210; Bacteria.
DR OrthoDB; 9765670at2; -.
DR Proteomes; UP000000737; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000000737}.
FT DOMAIN 49..372
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 393..670
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 70..77
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 795 AA; 89681 MW; 720A5F0A8A88F05F CRC64;
MTDDFDSDLN SPSSSTQTLH PASVSLTLTG NDSKAIPASR EAALQGIRDG LRPGQQQMAD
WEGGPLAVSA VPGAGKSTGM ASAAAIAIAR YHLNTHRQLV VVTFTRAAAA NIRSKINEQL
KNLGLPMGGF LVYTLHALAL NIARQHPELS GLDLENSTLI LPTPSNRLTR TCVELWINNY
PRHYQRLIEG MQFDGEETER LRRQSVLRTE VLPDLSWKVI QEAKSSGLKP SDLRDLATII
PDEYEILAIA AGLYENYEKL LKQRQFIDYD EMILAALRVL KNDRVCQQWQ ERVFAVFEDE
AQDSTPLQTE LLKILATDST SDNILNLVRV GDPNQAINST FTPADPIYFR NFCQDCQQID
RLATMDQAGR SSQIIIDAAN FVLKWVNNSQ LAGTEKPFQA QEIRPVTEGD PQSNPNPSPV
GLGLELYRPV DVYQTVELIA ERVIQLIQDN PDGKFAILVR ENKQGEFISN LLTRPDEFNF
KVDLREHPIK IYDASLAARN SRIPAEILSL LQFIDRPHSP DYLKAALKVF SDRQLIPNQD
FNALVIQPEE FLYPGPLETS PSDQVRKCRL FCRGLLQARL ELAPFQLISF LALTLQYERS
ELATADKLAE RIVKQTLGNN SIPAIVNVLN EIVSSERFET VDIVDQDESN ESIFTRKGQL
TIITMHKAKG LDWDYVFLPF LHEQTIPGSL RVLPQSRFLG EFTLSEVARA QIRANLHQQH
PLPNVMQAWE QAGYLKTAEE YRLLYVAMTR AKQLLWMSAA RQSPYSWHKP ENLQDQKPCP
ILPALKERFP DHFKS
//
