ID A0Z8B2_9GAMM Unreviewed; 402 AA.
AC A0Z8B2;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:EAW39840.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:EAW39840.1};
GN ORFNames=MGP2080_08439 {ECO:0000313|EMBL:EAW39840.1};
OS marine gamma proteobacterium HTCC2080.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales; Halieaceae.
OX NCBI_TaxID=247639 {ECO:0000313|EMBL:EAW39840.1, ECO:0000313|Proteomes:UP000004719};
RN [1] {ECO:0000313|EMBL:EAW39840.1, ECO:0000313|Proteomes:UP000004719}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTCC2080 {ECO:0000313|EMBL:EAW39840.1,
RC ECO:0000313|Proteomes:UP000004719};
RX PubMed=20472793; DOI=10.1128/jb.00511-10;
RA Thrash J.C., Cho J.C., Ferriera S., Johnson J., Vergin K.L.,
RA Giovannoni S.J.;
RT "Genome sequences of strains HTCC2148 and HTCC2080, belonging to the
RT OM60/NOR5 clade of the Gammaproteobacteria.";
RL J. Bacteriol. 192:3842-3843(2010).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAW39840.1}.
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DR EMBL; AAVV01000013; EAW39840.1; -; Genomic_DNA.
DR AlphaFoldDB; A0Z8B2; -.
DR eggNOG; COG0183; Bacteria.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000004719; Unassembled WGS sequence.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000004719};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:EAW39840.1}.
FT DOMAIN 6..229
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 279..401
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 92
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 358
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 388
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 402 AA; 42541 MW; 26FD2CA754FCB322 CRC64;
MTTTAYIYDA VRTPRSKGKK DGTLHEVKPV DLGGGLLRAL QSRQDLDTSY VDDVVMGCVT
PIGEQGSDVA KMIVQNADWD ESVAGVQLDR FCASGLEAVN IAAQKVASGW EDLVVAGGIE
CMSRVPMGSN GGAMGSDPGF SMKTGFVPQG IGADTIATLA GWSREDVDAY ALQSQQRATH
ARDSGWFDGS VIPVKDECGI TILERDDFIK PQTTMEGLAK LKASFEMHGG LGFDDIIMNK
YSELDRINHV HTPGNSSGIV DGSSAVLIGS ERAAKDLGLK PRGRIVATAV LATDPIIMLT
GPGPAAMKCL KKAGMTKADI DLWEINEAFA SVVLRYMQDL DLDPEVTNVN GGSIAMGHPL
GATGGCLVST MLDELERRDA KRAMLSLCVG GGMGISTIIE RV
//
