ID A0ZDR6_NODSP Unreviewed; 887 AA.
AC A0ZDR6;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Chloride channel protein {ECO:0000313|EMBL:AHJ26958.1};
GN ORFNames=NSP_6090 {ECO:0000313|EMBL:AHJ26958.1};
OS Nodularia spumigena CCY9414.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Aphanizomenonaceae;
OC Nodularia.
OX NCBI_TaxID=313624 {ECO:0000313|EMBL:AHJ26958.1, ECO:0000313|Proteomes:UP000019325};
RN [1] {ECO:0000313|EMBL:AHJ26958.1, ECO:0000313|Proteomes:UP000019325}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCY9414 {ECO:0000313|EMBL:AHJ26958.1};
RX PubMed=23555932;
RA Voss B., Bolhuis H., Fewer D.P., Kopf M., Moke F., Haas F., El-Shehawy R.,
RA Hayes P., Bergman B., Sivonen K., Dittmann E., Scanlan D.J., Hagemann M.,
RA Stal L.J., Hess W.R.;
RT "Insights into the physiology and ecology of the brackish-water-adapted
RT Cyanobacterium Nodularia spumigena CCY9414 based on a genome-transcriptome
RT analysis.";
RL PLoS ONE 8:E60224-E60224(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP007203; AHJ26958.1; -; Genomic_DNA.
DR RefSeq; WP_006195704.1; NZ_CP007203.1.
DR AlphaFoldDB; A0ZDR6; -.
DR STRING; 313624.NSP_6090; -.
DR PATRIC; fig|313624.11.peg.604; -.
DR eggNOG; COG0038; Bacteria.
DR eggNOG; COG0517; Bacteria.
DR eggNOG; COG0589; Bacteria.
DR HOGENOM; CLU_016449_0_0_3; -.
DR Proteomes; UP000019325; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd01031; EriC; 1.
DR CDD; cd01988; Na_H_Antiporter_C; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR PANTHER; PTHR45711:SF10; CHLORIDE CHANNEL PROTEIN; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00582; Usp; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 4: Predicted;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 59..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 450..505
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 521..582
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 887 AA; 95330 MW; 14F86EA65D2F24E2 CRC64;
MAISGLTQRF RLWLQPTRGL AIAEACIIGL VAALSAVFLK FGSGFLGTWR VQTSQIVPAL
LVLPTIGLSF GFIAGSLVNR FAPEASGSGI PQVKATLANV PITLSWRVAT VKLISAIITL
GSGMALGRQG PTVHVGAGLA AGMSRWVPTS PDHRRQMIAA GAGAGLAAAF NAPITGVLFI
VEELLQDLSG LTLGTAIIAS FIGGVVSRLL GGGSLQLNLE LLQYASNFTL PEIPFFVLLG
ILAGFLGALF NRGLIASIKI YQNLHLSLPL KMALAGCISG LLVAMLPESF RDYAGLREYM
IISEANITFA AIAFLSQFLL TLVAFGSGAP GGLFAPSLIL GSCLGHLVGV SASYFLAVDS
PTTYALAGMG GFFSAVSKVP ITAIVIVFEM TTDFNLVLPL MIVSVAAYLV SDKVMPGSLY
DKLLQLKGIT ITKAVSPEGI LTKLTANDVM QHRVETLDAD MTLEEAMQVF SRSHHRGFPV
VENGKLIGII TQSDFVTKRD SDSYILSNSQ SPKDVSLREI MIHSPITVKP KHHLSNVLYL
LDRYQISRLP VVEGRKLVGI ITRADIIRAQ AEHLNYGNVT PESQPEPSYV VYQTRSPNIG
RGRLLVPVAN PETAAILLQM AAAIARDRHY EIECVQIILV SRHNSPSETS VRTAKSRRLL
RQAEVLAKKW KIPLHTQIRV AHDPAEAILE TIHERHINLI LMGWKGETST PGRIFGNVVD
TIIRQATCDV MLVKLGNTPH SLLPIPHSPF PTPKFNRWLV TMAGGPNVRV AIKLLPALAT
LGDNPYIRLT QVFKPSQLKP DMTVLEQAIR ILMRRRKLSS NVVAIPVQAD SVAEGVINLV
KTEGYDVVVL GASREGLLQQ AVQGNIPEAI ASGVDCTVIL VRGAISS
//
