ID A0ZWT4_DROME Unreviewed; 1366 AA.
AC A0ZWT4;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Thiolester containing protein II, isoform E {ECO:0000313|EMBL:CAJ00624.1};
DE Flags: Fragment;
GN Name=TepII {ECO:0000313|EMBL:CAJ00624.1};
GN ORFNames=CG7052 {ECO:0000313|EMBL:CAJ00624.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:CAJ00624.1};
RN [1] {ECO:0000313|EMBL:CAJ00624.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Gabon line G191 {ECO:0000313|EMBL:CAJ00624.1};
RA Kim K.W.;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAJ00624.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Gabon line G191 {ECO:0000313|EMBL:CAJ00624.1};
RX PubMed=17103056; DOI=10.1007/s00239-006-0005-2;
RA Jiggins F.M., Kim K.W.;
RT "Contrasting evolutionary patterns in Drosophila immune receptors.";
RL J. Mol. Evol. 63:769-780(2006).
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DR EMBL; AJ973633; CAJ00624.1; -; Genomic_DNA.
DR VEuPathDB; VectorBase:FBgn0041182; -.
DR ChiTaRS; Tep2; fly.
DR ExpressionAtlas; A0ZWT4; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.2950; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF176; GH01829P-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT DOMAIN 422..556
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 636..728
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1254..1344
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
FT COILED 728..755
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAJ00624.1"
SQ SEQUENCE 1366 AA; 151815 MW; 629E954B20F2443E CRC64;
IYSVVGPGTL RSNSKYNVVV SVHKADGPSQ IKVSLNGPSY NETKQIELPP MSTQNVEFEV
PKLATGNYNL TAEGLSGVVF KNSTKLNYAD KKPSVFVQTD KATYKPADLV QFRILFLDEN
TRPAKIKKPI SVIITDGAQN RIKQLSDVKP TKGVFSGELQ LSEQPVLGTW KISVSVDGDN
RETKSFEVDK YVLPKFEVVV DTPKAVVIAD KVIKATIRAK YTYGKPVKGK ATVSMERSYG
YFGDLNANGN KQEKTIDVDG KGHVEFDIIH WAQRGQYLPP IKLFAVVTEE LTGNKQNATA
TVVLHQQRYS IEPYERPEHF EANKSFIYQV VVKNVDGSPV TNSAKNVKIG FDKSYSYFHE
PSPKTRINFE APVNENGIAT FNVRLPDSDS RYYRIFASFD GSENTIGSIS KFEPTLMSRE
PLKIQVNTKK PRLGEQVSFD VVSIKDLPYF VYTIVARGNV ILSDYVDVSD GQKSYTVKFT
PTFSMVPKAT IYVYYVVNND LQFEEKTIDF EKEFSNSIDI SAPTNAKPSE EVKLRIKTDA
DSFVGLLGVD QSVLLLKSGN DLSQDDIFNS LNIYQTSTPW MNGYGRYPGQ TSGLVTLTNA
NYPYNTEDSI SYDEVDAISI TSSTKIELVR TNFAEVWMWT TSDNGSVGEE FTLTKKIPDT
ITSWVVTGFS LNPTSGIALT KNPSKIRVFQ PFFVSTNLPY SVKRGEVIAI PVVIFNYLDK
TLDADVVMDN SDQEYEFTEA TNEVLEKAID EVRRVKRVTI PANSGKSVSF MIRPKNVGFT
TLKITATSAL AGDAIHQKLK VEPEGVTLFE NRAVFINLKD QPEMSQSLDA DIPNEVVPQS
EFIEFSVVGD LLGPTLQNLD NLVRMPYGCG EQNMVNFVPN ILVLKYLEVT GRKLPSVESK
ARKFLEIGYQ RELTYKHDDG SYSAFGKSDA SGSTWLTAYV MRSFHQAGTY TDIDPKVITA
GLDFLVSKQK ESGEFPEVGK LFDNANQNPL ALTSFVLLAF FENHELIPKY QSAIKKAVRY
VAEEADKTDD QYSLAIAAVA LQLAKHPQSE KVIAKLESVA RKENDRMWWS KATESTGEDG
RVFHWKPRSN DVEITSYVLL ALLEKDPAEK ALPIIKWLIS QRNSNGGFSS TQDTVIGLQA
LTKFAYKTGS GSGTMDIEFS SAGESKNTIK VNPENSLVLQ THDLPKSTRK VDFTAKGTGS
AMVQLSYRYN LAEKEKKPSF KVTPTVKDTP NQLLIVDICA EYVPLEDADK DKDSNMAVME
IALPSGFVGD STSLGKIQAV DRVKRVETKN SDSTVVVYFD SLTPGDVRCL PLEASKAHAV
AKQKPASVSL YDYYDTERKA TEYYQVKSSL CDICEGADCG EGCKKD
//
