ID A0ZWV0_DROSI Unreviewed; 1375 AA.
AC A0ZWV0;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Thiolester containing protein II isoform C {ECO:0000313|EMBL:CAJ18846.1};
DE Flags: Fragment;
GN Name=TepII {ECO:0000313|EMBL:CAJ18846.1};
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000313|EMBL:CAJ18846.1};
RN [1] {ECO:0000313|EMBL:CAJ18846.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Kenya line KY219 {ECO:0000313|EMBL:CAJ18846.1};
RA Kim K.W.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAJ18846.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Kenya line KY219 {ECO:0000313|EMBL:CAJ18846.1};
RX PubMed=17103056; DOI=10.1007/s00239-006-0005-2;
RA Jiggins F.M., Kim K.W.;
RT "Contrasting evolutionary patterns in Drosophila immune receptors.";
RL J. Mol. Evol. 63:769-780(2006).
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DR EMBL; AM050188; CAJ18846.1; -; Genomic_DNA.
DR ChiTaRS; Tep2; fly.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02897; A2M_2; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 2.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 2.60.40.2950; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 2.60.40.690; Alpha-macroglobulin, receptor-binding domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR009048; A-macroglobulin_rcpt-bd.
DR InterPro; IPR036595; A-macroglobulin_rcpt-bd_sf.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR041813; A2M_TED.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF176; GH01829P-RELATED; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF07677; A2M_recep; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01361; A2M_recep; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF49410; Alpha-macroglobulin receptor domain; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Thioester bond {ECO:0000256|ARBA:ARBA00022966}.
FT DOMAIN 422..556
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 638..729
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
FT DOMAIN 1255..1345
FT /note="Alpha-macroglobulin receptor-binding"
FT /evidence="ECO:0000259|SMART:SM01361"
FT COILED 729..756
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAJ18846.1"
SQ SEQUENCE 1375 AA; 153036 MW; F76939F5D05CB20F CRC64;
LYSVVGPGTL RSNSKYNVVV SVHKADGPSQ IKVSLNGPSY NETKQIELPP MSTQNVEFEV
PKLSTGNYNL TAEGLSGVVF KNSTKLNYAD EKPSVFVQTD KATYKPADLV QFRILFLDEN
TRPAKIEKPI SVIITDGAQN RIKQLSDVKL TKGVFSGELQ LSEQPVLGTW KISVSVDGDN
RETKSFEVDK YVLPKFEVIV DTPKAAVIDD KVIKATIRAK YTYGKPVKGK ATVSMERSYG
YFGNPGGNDY KQEKTIDVDG KGHVEFDIIS WTQRGQYLPP VKLFAVVTEE LTGNKQNATA
TVVLHQQRYM IEAYERPDHF EANKSFIYQV VVKNVDGSPV TSSAKNVKIG FTNTFSYFNE
MPPVSRINYE APVNENGIAT FNVTLPDSKS RYYRIFASFD RSMSHLGSIS NFEPTIISRE
PLKIQVNTKK PRLGERVSFD VVSIEDLPYF VYTIVARGNV ILSDYVDVPD GKKTFTVKFT
PTFSMVPKAT IYVHYVVNND LQFEEKTIDF EKEFSNSIDI SAPTNAKPSE EVKLRIKTDA
DSFVGLLGVD QSVLLLKSGN DLSQDDIFNS LNKYQTSTPW MNGYGRYPGQ TSGLVTLTNA
NYPYNTDFAI AFSLAEEAPG MGSPPTSPPK IRKEFPENWI FYNAEXXXXX XLTLTKKIPD
TITSWVVTGF SLNPTSGIAL TKSPSKIRVF QPFFVSTNLP YSVKRGEVIA IPVVIFNYLD
KTLDADVIMD NSDQEYEFTE ATNEVLEKAI DEVRRVKRVT IPANSGKSVS FMIRPKSVGF
TTLKITATSA LAGDTIHQKL KVEPEGVTQF ENRAVFINLK DQPEMSQSLD AEIPTEVVPQ
SEFIEFSXXX XLLGPTLQNL DNLVRMPYGC GEQNMVNFVP NILVLKYLEV TGRKLPSVES
KARKFLEIGY QRELTYKHDD GSYSAFGKSD ASGSTWLTAY VMRSFHQAGT YTDIDPKVIT
AGLDFLVSKQ KESGEFPEVG KLFDNANQNQ LALTSFVLLA FFENHELIPK YQGAIEKAVR
YVAEEADKTD DQYSLAIAAV ALQLAKHPQA EKVLAKLESM ARNENDRMWW SKTTESTGED
GRVFHWKPRS NDVEITSYVL LALLEKDPAE KALPIIKWLI SQRNSNGGFS STQDTVIGLQ
ALTKFAYKTG SGSGTMDIEF SSAGESNNTI KVNPENSLVL QTHVLPKSTR KVDFTAKGTG
SAMVQLSYRY NLAQKEKKPS FKVTPTVKDT PNQLLVVDIC AEYVPLEDAD KEKDSNMAVM
EIALPSGFVG DDESLGKIQA VDRVKRVETK NSDSTVVVYF DSLTPGDVRC LPLEASKAHA
VAKQKPASVS LYDYYDTDRK ATEYYQVKSS LCDICEGADC GEGCKKDWGP GVKRW
//
