ID A0ZX72_DROME Unreviewed; 492 AA.
AC A0ZX72;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Gram-negative bacteria binding protein 1 {ECO:0000313|EMBL:CAJ18920.1};
GN Name=GNBP1 {ECO:0000313|EMBL:CAJ18920.1};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:CAJ18920.1};
RN [1] {ECO:0000313|EMBL:CAJ18920.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Netherlands line N30 {ECO:0000313|EMBL:CAJ18920.1};
RA Kim K.W.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAJ18920.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Netherlands line N30 {ECO:0000313|EMBL:CAJ18920.1};
RX PubMed=17103056; DOI=10.1007/s00239-006-0005-2;
RA Jiggins F.M., Kim K.W.;
RT "Contrasting evolutionary patterns in Drosophila immune receptors.";
RL J. Mol. Evol. 63:769-780(2006).
CC -!- SIMILARITY: Belongs to the insect beta-1,3-glucan binding protein
CC family. {ECO:0000256|ARBA:ARBA00008781}.
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DR EMBL; AM050248; CAJ18920.1; -; Genomic_DNA.
DR AlphaFoldDB; A0ZX72; -.
DR VEuPathDB; VectorBase:FBgn0040323; -.
DR HOGENOM; CLU_019533_2_0_1; -.
DR ExpressionAtlas; A0ZX72; baseline and differential.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR CDD; cd02179; GH16_beta_GRP; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.2140; Beta-1,3-glucan-recognition protein, N-terminal domain; 1.
DR InterPro; IPR031756; BGBP_N.
DR InterPro; IPR043030; BGBP_N_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000757; GH16.
DR InterPro; IPR035806; GH16_GRP_C.
DR PANTHER; PTHR10963; GLYCOSYL HYDROLASE-RELATED; 1.
DR PANTHER; PTHR10963:SF70; GRAM-NEGATIVE BACTERIA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF15886; CBM39; 1.
DR Pfam; PF00722; Glyco_hydro_16; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS51969; CBM39; 1.
DR PROSITE; PS51762; GH16_2; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..492
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002631923"
FT DOMAIN 20..120
FT /note="CBM39"
FT /evidence="ECO:0000259|PROSITE:PS51969"
FT DOMAIN 135..492
FT /note="GH16"
FT /evidence="ECO:0000259|PROSITE:PS51762"
FT REGION 126..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 492 AA; 55289 MW; 1330E5FF4343BA60 CRC64;
MPGLCIGILL LIGFGCTTAY KIPTPTVELL ETGFSVSIPD EEGVKVVAFN VNRNRNFTSF
INEGQYNVRL TEPQNGRWTT NFSSVPLRSQ DVLYLWTSVQ HQKAVYQDLA QPLPVCNLGG
EYRPRGCSPG DDDFTDDNQL STEDSALEPT APSVCEPSES QVSPQIGVSI CKGQLLFEET
FDQLNESLWI HDVRLPLDSK DAEFVLYDGK AKVHDGNLVI EPLLWSSYRP DLAIANSRLD
LSERCTGTHN RIKECILHST GSGPSGIMPP IVTPRISTKE TFAFQYGRIE IRAKLPKGDW
IVPLLLLEPL TEWYGQSGYE SGQLRVALAR GNSVLRMPRG KLVDGRSLYG GPVLSTDAQQ
REDLWLSKRK ISHFGDDFHT YSLDWSSNRL LFSVDGQVYG EMLNGFTELD ENPRWKQGGP
MAPFDKMFYI SLGVSVGGFG DFVDHLRTAT YEKPWANYHP QAKLQFHQAQ DQWLPTWKQP
ALKIDYVRVF AN
//
