UniProt: A1C2E8

Database: UniProt
Entry: A1C2E8_HUMAN

LinkDB:  A1C2E8_HUMAN 
Original site:  A1C2E8_HUMAN

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Ontology (6)   
   GO (6)   
DNA sequence (12)   
   EMBL (12)   
Protein domain (10)   
   InterPro (5)   
   Pfam (2)   
   PROSITE (2)   
   SMART (1)   
Literature (1)   
   PubMed (1)   
All databases (29)   

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ID   A1C2E8_HUMAN            Unreviewed;       375 AA.
AC   A1C2E8;
DT   23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT   23-JAN-2007, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   RecName: Full=Growth/differentiation factor 8 {ECO:0000256|ARBA:ARBA00023852, ECO:0000256|RuleBase:RU369049};
DE            Short=GDF-8 {ECO:0000256|RuleBase:RU369049};
DE   AltName: Full=Myostatin {ECO:0000256|ARBA:ARBA00031866, ECO:0000256|RuleBase:RU369049};
GN   Name=GDF8 {ECO:0000313|EMBL:ABI48370.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABI48370.1};
RN   [1] {ECO:0000313|EMBL:ABI48370.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17186467; DOI=10.1086/509707;
RA   Saunders M.A., Good J.M., Lawrence E.C., Ferell R.E., Li W.-H.,
RA   Nachman M.W.;
RT   "Human adaptive evolution at myostatin (GDF8), a regulator of muscle
RT   growth.";
RL   Am. J. Hum. Genet. 79:1089-1097(2006).
CC   -!- FUNCTION: Acts specifically as a negative regulator of skeletal muscle
CC       growth. {ECO:0000256|ARBA:ARBA00023756, ECO:0000256|RuleBase:RU369049}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with WFIKKN2, leading
CC       to inhibit its activity. Interacts with FSTL3.
CC       {ECO:0000256|RuleBase:RU369049}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC       ECO:0000256|RuleBase:RU369049}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR   EMBL; DQ927047; ABI48370.1; -; Genomic_DNA.
DR   EMBL; DQ927052; ABI48375.1; -; Genomic_DNA.
DR   EMBL; DQ927060; ABI48383.1; -; Genomic_DNA.
DR   EMBL; DQ927071; ABI48394.1; -; Genomic_DNA.
DR   EMBL; DQ927076; ABI48399.1; -; Genomic_DNA.
DR   EMBL; DQ927077; ABI48400.1; -; Genomic_DNA.
DR   EMBL; DQ927095; ABI48418.1; -; Genomic_DNA.
DR   EMBL; DQ927108; ABI48431.1; -; Genomic_DNA.
DR   EMBL; DQ927112; ABI48435.1; -; Genomic_DNA.
DR   EMBL; DQ927115; ABI48438.1; -; Genomic_DNA.
DR   EMBL; DQ927118; ABI48441.1; -; Genomic_DNA.
DR   EMBL; DQ927142; ABI48465.1; -; Genomic_DNA.
DR   PeptideAtlas; A1C2E8; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:2000818; P:negative regulation of myoblast proliferation; ISS:AgBase.
DR   GO; GO:1902725; P:negative regulation of satellite cell differentiation; ISS:AgBase.
DR   GO; GO:1902723; P:negative regulation of skeletal muscle satellite cell proliferation; ISS:AgBase.
DR   CDD; cd19388; TGF_beta_GDF8; 1.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF150; GROWTH_DIFFERENTIATION FACTOR 8; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues {ECO:0000256|RuleBase:RU369049};
KW   Cytokine {ECO:0000256|ARBA:ARBA00022514, ECO:0000256|RuleBase:RU369049};
KW   Disulfide bond {ECO:0000256|RuleBase:RU369049};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|RuleBase:RU000354};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU369049};
KW   Signal {ECO:0000256|RuleBase:RU369049, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..375
FT                   /note="Growth/differentiation factor 8"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010102106"
FT   DOMAIN          263..375
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
SQ   SEQUENCE   375 AA;  42790 MW;  E907E6DCF82C97F2 CRC64;
     MQKLQLCVYI YLFMLIVAGP VDLNENSEQK ENVEKEGLCN ACTWRQNTKS SRIEXIKIQI
     LSKLRLETAP NISKDVIRQL LPKAPPLREL IDQYDVQRDD SSDGSLEDDD YHATTETIIT
     MPTESDFLMQ VDGKPKCCFF KFSSKIQYNK VVKAQLWIYL RPVETPTTVF VQILRLIKPM
     KDGTRYTGIR SLKLDMNPGT GIWQSIDVKT VLQNWLKQPE SNLGIEIKAL DENGHDLAVT
     FPGPGEDGLN PFLEVKVTDT PKRSRRDFGL DCDEHSTESR CCRYPLTVDF EAFGWDWIIA
     PKRYKANYCS GECEFVFLQK YPHTHLVHQA NPRGSAGPCC TPTKMSPINM LYFNGKEQII
     YGKIPAMVVD RCGCS
//

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