ID A1CBM8_ASPCL Unreviewed; 470 AA.
AC A1CBM8;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=ACLA_015920 {ECO:0000313|EMBL:EAW13146.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW13146.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW13146.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; DS027049; EAW13146.1; -; Genomic_DNA.
DR RefSeq; XP_001274572.1; XM_001274571.1.
DR AlphaFoldDB; A1CBM8; -.
DR STRING; 344612.A1CBM8; -.
DR EnsemblFungi; EAW13146; EAW13146; ACLA_015920.
DR GeneID; 4706549; -.
DR KEGG; act:ACLA_015920; -.
DR VEuPathDB; FungiDB:ACLA_015920; -.
DR eggNOG; KOG1684; Eukaryota.
DR HOGENOM; CLU_009834_22_0_1; -.
DR OMA; EWEKSDM; -.
DR OrthoDB; 3639304at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EAW13146.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701}.
FT DOMAIN 44..388
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 470 AA; 52147 MW; AFC0E361F84A3573 CRC64;
MPLRAKVTNP AFGAAAKMST APELPKELPG DEPDDVLFNS LYGVRLIELN RPKKLNSLNG
SMARKILPRL KEWEKSQLAN IVMLSGAGTK ALCAGGDVAA LALQNEKGPE GQQASADFFG
LEYRLDHVIA TYTKPFISVM DGITMGGGVG LSVHAPFRIA TERTVFAMPE TTIGFFPDVG
GSFFLPRLDG EIGTYLALTS ERLNGVQALY AGVATHYLHS SVLSNLTARL SELVFRDQAS
LPERLDLVNK TMAEFSIGLP SLEQEPIHLA GSLRSAIDRC FGHSTIEEIF KALEQETVQK
EWAQRTLETL SSRSPTSLKV TLRQMRVGKQ WTISETFQRE YQIAAQFMKH PDFVEGVKAR
LMSKPPRQAT WQPATLGEVT NDAVDVFFKL PEGESRLSLF NKINYKQYPH AYGLPSEAEI
EKFVRDSSES ANKTVSEFVQ KWGHKEGVRE KVAEVLARRT VQTPEGLRWE
//
