ID A1CFN0_ASPCL Unreviewed; 6199 AA.
AC A1CFN0;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Nonribosomal peptide synthase, putative {ECO:0000313|EMBL:EAW11679.1};
GN ORFNames=ACLA_093780 {ECO:0000313|EMBL:EAW11679.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW11679.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW11679.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SIMILARITY: Belongs to the NRP synthetase family.
CC {ECO:0000256|ARBA:ARBA00029454}.
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DR EMBL; DS027052; EAW11679.1; -; Genomic_DNA.
DR RefSeq; XP_001273105.1; XM_001273104.1.
DR STRING; 344612.A1CFN0; -.
DR EnsemblFungi; EAW11679; EAW11679; ACLA_093780.
DR GeneID; 4704804; -.
DR KEGG; act:ACLA_093780; -.
DR VEuPathDB; FungiDB:ACLA_093780; -.
DR eggNOG; KOG1177; Eukaryota.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000022_60_0_1; -.
DR OMA; PREIEHH; -.
DR OrthoDB; 2787863at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 5.
DR CDD; cd19542; CT_NRPS-like; 4.
DR CDD; cd19534; E_NRPS; 1.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 5.
DR Gene3D; 1.10.1200.10; ACP-like; 6.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 6.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 5.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 7.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 5.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 6.
DR SMART; SM00823; PKS_PP; 4.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 13.
DR PROSITE; PS00455; AMP_BINDING; 4.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701}.
FT DOMAIN 772..846
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1856..1932
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2955..3031
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4493..4567
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5560..5636
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 6199 AA; 681708 MW; A3E325C994224273 CRC64;
MSGSTEMATA TEKLLDTVCS FPALLNEEDE LPIATRAQVE VELPSHEVIR DFSLKYGISI
QVVLETVWAI ALKTFTGDEN ICLASLSQEG SDLITAAVED DSTLIDVLGV ISKNKKHFQD
GYAPSDLSCN SGVCFVESTE QIVSNFDQFD VLLHAVIDQS QWRLSLWYQT SHLAHPYATI
VAATVSQILG EILADPSRPL SQINLVHPQV RHELQAWSNM TPASIDRCVG EMFEKTVQER
PLHTAVNTSD LTLTYQELDF RSATLARELQ KRGVVPEAIV VLCFPKSAWA VVAMMAVIRA
GGAILFLDPS HPTARHQEII GQVDTKWIIT APEYSQLWEW FDGDVLLLDD NFVSSLGQSP
DNESTKEQKV QCSATPSSAL YVIFTSGSTG KPKGCVVEHR QFLTGSLAQQ KASKMTHEDR
VLQLASFTFD VSILEIITSL ISGACVCIPN DQERAKGPAA CIQQFGVTWA FLTPSLVNLM
APEMVPTLQF LVLGGEAVQQ ENINIWAPHV RLANGYGPTE CSIAATAHPG LSLKTSPSNI
GHPLGGCCWI VDKDNHNRLL PIGAPGELVI QGPIVARGYL NELEKTRAVF LESVQWMESG
PTDTSRLYKT GDLARFNADG SLFFLGRKDS QVKLRGLRIE LGEIEHRLAD HPLVEQAVVV
LAKQGPCQGK LCAVLSLKSL RQDTVSLELV EDGKFGLATE EIATVAAALS QQLPSYMQPT
VWAPVQCIPL TVSGKQNGVL VRKWVADMSL ETFDLLTGRT EGADSEKVQP STDEEIELQA
LCSAILGFAS PEDIWLNKSF IQNGGDSIQA MQLLDHLRRK QYGVGLEDLL QSTTLIDLAQ
RMASNERVTS VEEESAVVSL NLERIKQLGF NVSDVEDLYP VSSVQRGILL SQQQSPDRYQ
LRITCEILPP SGQSVKLELL REAWKQLTKR HPALRTVFVE AEAEDGLCDQ LVLTSGHGAF
MEWSHNDETA VWAALNAYKR EDEPLQPPVA FIVSHTSDGK VFGTIDISHA LIDGVSILIL
LRDLSQAYAG LMDSQIVRYA PYIQYLQTLP SNDSLEYWTK YLDDASPCHF PALNDDLTSE
NQLHELTINM EDADAIQKFC ATHNVTPATV FQAAWALVLK AYTGQDDVCF GYLTAGRDFP
VPNISNAVGV FINMMTYRMR LAATDTVADV IKETQEGFLR GLSHQQCSIA EIQHALGVSQ
PLFNTIMSLQ SALGEEIAGA DIDKTIRFRV VNEQDPTEYN ISVNVFVSKV RVSLTLRYFT
EVLSDGMAAN VFDTFHDVVQ TLIHSYNSTL PTLTVLSERD QSQIASWNQT QWPDVHACVH
DLVHQQVLSR PSATAIEAWD GSFTYKELDE VTTSLACILR ENGVGPEVLV PICFSKSSWT
VIAQLSTLKA GGACVAFDPE HPQSRREEML RQCGATIALV GEGKESLFHG LVDRVVLVAP
GSIPNLPTQQ LKEAPSASPN SPAFVVFTSG STGKPKGIVL EHHALCSSAR AHGPAMNYGP
DARVLQFASY TFDVSIGETF TCLMSGGTLC IPNEDERLND LAGVINRMNT NVVYLTPSVV
SLLQPSQVPG VHTLALGGEA VREDNILTWA DQTNLVNIYG PAECSVWSTG LTGVPRSASP
RNIGYGLGAR MWITHADDPS QLCAVGAVGE ILIEGPIVAR GYLGDEAKTA AVFISPPAWL
SKFDSHAAQQ SIKLYRTGDL AHYNSDGSIN FVGRRDHQVK LHGQRVEMGE IDHALLSHEA
VQNALALVPK QGALKGKLVA VISLKRKSSV PATDRKGMAL LEDADSEDVQ TDIVAVRQRV
SSLLPGYMVP AHWLTVQTIP MTRNGKSDRP SVTVWVEQLS EDPTGAANHL DRGDDGPQSP
IETELQHVIS EVLNLSLGQV AMEQSFLALG GDSITAMQVS SRSRSRGLQV AVKNILKGKS
IREIASQATL RSNLDQSGLN GASDIRQFSL LPRVEAADID ALASKAGYNG AVAIEDAYPC
SPMQEGILIS QAQAPETYKF YAVCSIRSTN PAEPVSLARL HKAWTRLVAR HPSLRTFFVE
GLAHDGLYSQ VVLKEHTPQL ETASDLTTLF QYPEEYPLDY QKSSPPHRLI VLQDQEGATH
FNLEISHTLI DGGSMAIILR DLAKAYDGEL QPGPLYRDYI AMLRNQSMEE TLLFWTSYLE
NVKPVFFPSL LDAPATATRK LQAINIPIAP ATVLDLQTFT KQHEVTLANV FQSVWALVLR
AYTGESDIVF GYLSSGRDVE GLDMDMDNAV GAFITMLACR AQIDDDLTLL DVTRRMHEDF
INSLPYQQTS LAQVQHALKL SGERLFNSIL SLQRPMVDSN NESSIAIEYL GGSDPTEYDL
GVSITVSDTA IEVSINYWST FMESEQADML ASTFTNILSK LIDAPTKAIE QVDLLGQKHM
EYILDVNHNG QVPETVNDCI HTRIHRRALT HPDAPAIHSW DASLSYGELD KLSSRLAGAI
ISLGVTVEDA VPLCFDKSAW AMVSMLAVLK AGAAYVSMNP SHPTQHLASI IAQTKARIVL
VGSSAYSDKV KSLVDNVLVV DPALFHTLPE PNQAIFPPVS SSNAAMINFT SGSTGKPKGI
VVLHKGLCSL TIHNEDMQLD HSSRVLQFSA YTFDTSNSEM FFTLCRGGCV CVPSDDDRLN
DLAGAINRFQ VTYAYLTPSV ALTLSPESVP TLKTLALVGE AVPADLARKW QDRLHLINSY
GPAECTIMSS FNVIREGVAA ANIGKAHGCL FWVTEPEDSQ RLVPVGRVGE LLIEGPLVTR
GYLDPELTTK VFIQPPRWRG PTLHGTRLYK TGDLVRYAAD GSLVYVGRKD SQIKLNGQRV
EMGEVEKTIA SDSLVQQCVI LLPKQGPSKK KLVAVVVLEE FLDDECQEIT PIVNPTDKSR
AISQVDSIRE RLASVLPSYM IPSVWLVCLK FPYTPSRKVD RPRISQWVEK MDHETYVQAA
AEEQIETSES IDDTPSEANT AAQLRNIVAR VLNISSSQAS LSRSFLSLGG DSITAMQLVV
QCRNEGLQIL FKDVMRSTSI AALAQCAENV DSRRSSDRAA EQWDTPFGLS PIQQLYFQEI
SQGATDAAAN QFNQSFLLRL TQDVSIDQLR SALDRIMQRH SMLRARFRKS HRGEWTQIIP
SQVSGSYRFR VHTIESEDEA RALSLKAQSQ LDIQNGPVFA AEIFTVADKP TLLFLVAHHL
VIDLVSWRIL FQEVEDSLTD KASLSDLAPF SFQRWQRQQA DYASKHLRPK MVLPYSIPPA
DYEFWGMKDV PNYQEETVQL SATLDAHDTE LLLSHSHKAM RTEPLDILIA ALLSSFKDTF
GRQPPAIFNE GHGRQPAVNG PLSDIDLSDS VGWFTTVFPF HVPVEASGNS LDIVRQVKDQ
RKELPANGWS YFTSKYHNED GTREFANHMP VEVLFNYLGL YQGLERADGV FQRVPFNEGD
VGPSVRRYAL FEINVYVVNG SAHATIAFNR NMKHQEQVTE WLSRYTVALR ELSQQLMNTQ
YTLTRSDYPL LSISYPKLDH LHTQRLPELG YQIDSIEDIY PCSPLQEGIL LSQTRMPDAY
LYHAILRLTS AQGRPVDPQQ LISSWQQVVD RHSILRTAFL ERVSSRPFDQ MVLVDHQANS
LVLGGVGSEK EAIDILGSLA PLSSSSNKPQ HRLAVVQAND ETIYFKLDIS HALMDGTAMA
ILIHDLASAY INQLPLTPAT SYSEYIGYIQ SQPADEALEF WATHLAGVQP SHFPALTSDS
SKEQRELQHI DVPVPEIAKV RTFCQQHDVT LANIVRLAWA VVLSAYTGEE NICFGYLTAG
REVPVPGVES AVGPFINMLV CAMDMSQMGQ KTVVEELKAL HEEYLQNLPY QHVGLAEIQH
RLGLSGQTLF NTVVSFQRRD VDNFQLGDLK IDYIQGEDPT EYDITLNVTD TDRGFTVQLG
YLTSRLSSEQ ALNVSEALSA ALSSIVSAPR SPVTSVDLFS SRHREQVLQW NKTIPATIDE
CLHSLFERSA KASPDALAIA SWDEDLSYAQ LDKKTTQLAR VLVSMRLGPD DLVPICFDKS
SWAIVAMLGI LKAGAGFVPL DPAHPPERLA SIIAQTSSSL ALVSLSTSKR VVDLVPNILV
ISSGSNMWLD SDDSLTLPAA PTTRNIAYTL FTSGSTGTPK GVVVEHSAVS TSIIHHGKEI
GCSPATRMFQ FAAYTFDACI LEIFTTLAYG GCICVPSEAD RMSDIAGSIR RLQANTTFLT
PSVVRILRPD QVPTLSTIIL GGEALDRDNI QTWAAGSDMR LMNGYGPTET CVFCVMHTFT
SKTERHDILG RAVSSLSWIV RPGDHNHLAP IGSVGELLVQ GGTLARGYLH DDDKTAKSFI
VNPDFATSGP DTGAQRFYKT GDLVRYNADG TITYLGRKDT QIKLRGQRIE LAEIEHQIQR
QLPPNVQIAV EVVLPHGEKE QALLAAFICQ PSSQPDFLQE MTPEARAQLG QLKQSLFTVL
PPYMQPSLFL PTNWMPTTSA KKLDRHFLRS HCASLTDVQL KVYSLQGEES RRAPNTVLEK
KVQELWHRVL KVPMQQIYAE DSFFQVGGDS IAAMKMAATS DDISITVADI FRHPVLADLA
AALAAKNQPE KTNGIPVEPF ELLSDYSVLK GISTEYGIPP ECIQDAYPST SLQEGMMALA
ILNPGAYVLR KVLKLTSSID IARFQSAWET VSQKTPILRT RLVPTTDGSL LQLVVNEHIE
WRSAQSLQDY LELDARESIR YGAPLVRYAI TADGHFVWTA HHSVYDGWSL PMILEQVRCA
YENGDCSDTP RFNTFIKHLV DIDPQSTRNF WQKQLEGQRP SSFPELPSPS YRPSVRGSTA
HKMSFSHSPN SPILKTTVLR AAWAFVLSFY TDSPDVVFGM TLSGRNGSVS GIDKMIAPVI
TTVPVRVAFP PAITVEGFLQ QVQQQATDMI PHEHFGLQNI ANLSSECARA IEFQNLFVIQ
PASELTTTTA FLGCEEVDLP LQDFDSYPLV VECYLADGDI HIETRHDEAI LSAWQVQNML
YHFESLVNQL TAVENAGRPI EQIEMFGEKD LQQILEWNQV YPEVVESTVP QVFAQQVAER
PSALAVDAWD GQLTYADLDY FSSILARHLH HLGVGPEVLV PMCFDKSRWA VVAQMSVIKA
GGACVNLDPK HPQARLETIV RDAGAPILLC APSHSGILGS ALSVHEVTVT EEFIRSLASS
NDMMASNLPD LSPRNAAYVL FTSGSTGKPK GIVIEHGSLC SSSKAHGSRW GIGPNTRLLQ
FAAYTFDVSC ADIFTTLQRG GCICVPSEHD RLNALPESIN HFRCNWAFLT PTVASLLPAD
NIPSLKTLVL GGEASSWDTI AKWHSVLDLI VCYGPAECSV YCSGAPPATA TSDPANLGAS
IGALYWIADP QDPNRLTPVG CVGELLLEGP TVAREYLHDP AKTASAFVRD PTWAPSRTHN
RPRMFYRTGD LVRYNEDGTI RFAGRKDTQV KVRGQRVELG EIEHAIRLAM PSLAHATVDA
VKDPSSARQT VVAFLHFSNR SGSAELMEMT AELRENLIQM QQTLSQSLPS YMIPSMFLPL
ARVPLTMNGK ADRRQLRDLA LSLSQDDVLA FSLADGVKQE PTTETEFQLR ELWVKLLNVE
VESIGAGDHF FRSGGDSIIA MKLTSLARAR GWPLSVQEVF QFPILSDMAA HIDNEPRAVD
ASSHVAYQPF SLIQTSGSEL VDQVATDVKT ASTNIADILP ATDFQSSAIA HSMMKTRGLL
NYLFLDGQGS LPWTVGYVQS VWSRFLSSHQ ILRTVFTARG DRFYQVVLKQ ISQEVEWYET
DRDIDSFCAE LCRDDVQSDL QLGDSLTKLI IVGSQTHHRV ILRLSHAQYD GVCLPQIWQT
LQDVFLGKTP SPEAPFAQYV AAVNSHNGAG TMAYWRTLLQ DSQMTNVVNH AKPSYRNVYD
LHLTRTIPVP VNSRPSSGIT FATILKASWA TVLAALSDTT DVVFGHVTSG RNIPGTDMER
IIGACLNIIP VRASVNSSTS ATDLLQSLQS QHIASMAHES IGMRQVVREC SSWAPFTRFS
SIVQHQNIEQ IAAVTLADRE YTIGDFCPAA DEADVAIKTT PLDGNQMEVL FITSSQSVGE
SVASTLLDLL CQTIQRFCQP DSAQLQSAPA QWLSGKSMLP LAYPSPIPTL TANGTVNGAP
SSSPNGVVSL IYDSWRLVLG APDLSLDLDS DFFLVGGDLV SVALLAATLR QHGFNIAVED
LIDRSVLQGM AETLLRSKA
//
