ID A1CH82_ASPCL Unreviewed; 1663 AA.
AC A1CH82;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN ORFNames=ACLA_047060 {ECO:0000313|EMBL:EAW10237.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW10237.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW10237.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|PIRNR:PIRNR002290}.
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DR EMBL; DS027054; EAW10237.1; -; Genomic_DNA.
DR RefSeq; XP_001271663.1; XM_001271662.1.
DR STRING; 344612.A1CH82; -.
DR EnsemblFungi; EAW10237; EAW10237; ACLA_047060.
DR GeneID; 4704135; -.
DR KEGG; act:ACLA_047060; -.
DR VEuPathDB; FungiDB:ACLA_047060; -.
DR eggNOG; KOG0985; Eukaryota.
DR HOGENOM; CLU_002136_0_0_1; -.
DR OMA; HCYDLLH; -.
DR OrthoDB; 5474327at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 3.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290}; Membrane {ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000006701}.
FT REGION 1606..1663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1620..1636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1663 AA; 189647 MW; 3832135AE5311D06 CRC64;
MAPLPIKFTE LINTLESDHY VCVRQKLNED DKPQVIILNL KNNNEVIKRP INADSAIMHW
SKNIIALRAQ GRTIQIFDLT AKQKLKSAVM NEDVVYWKWF SEKCLGLVTE ASVYHWDVFD
PTQNQPIKIF DRLPNLSGCQ IINYRVNDDE KWMVVVGISQ QQGRVVGSMQ LYSKDRGISQ
FIEGHAAAFA SIRVEGSPLE HKLFTFAVRT QTGAKLQIAE IDHQEPNPRF QKKAVEVYFP
QEAVNDFPVA MQVSRKYDIV YLVTKYGFIH LYDLETGTCI FMNRISSETI FTTAPDSDSA
GLVGVNRKGQ VLSVSVDEGT IIQYLMENPA MSGLAVKLAS KAGLPGADHL YQQQFDNLLA
QGNYSEAAKI AANSPRGFLR TPETINRFKN APQTGQQMSV ILQYFGMLLD KGSLNKYESV
ELVRPVLQQN RKHLLEKWTR ENKLEASEEL GDIVRPYDMN MALSIYLQAN VPNKVIAGFA
ETGQFDKILS YSKQVGYQPD YTQLLQHIVR VNPEKGAEFA AQLANEESGA LIDLDRVVDV
FLSQNMIQQA TSFLLDALKD NKPEHGHLQT RLLEMNLVNA PQVADAILGN EIFTHYDRPR
ISQLCENAGL IQRALENTDD PAVIKRNIVR TDKLNPEWLM NYFGRLSVEQ TIECMDTMLE
VNIRQNLQAV VQLATKFSDL LGPGRLISLF EKYRTAEGLY YYLGSIVNLS EDPEVHFKYI
EAATAMGQLT EVERICRESN YYNPEKVKNF LKEARLTEQL PLIIVCDRFN FIHDLVLYLY
QNQQYKSIEV YVQRVNPSRT PAVVGGLLDV DCDEAIIKNL LSTVEPSVIP IDELVSEVES
RNRLKLLLPF LEATLASGNQ QQAVYNALAK IYIDSNNNPE KFLKENDLYD TLTVGKYCEK
RDPNLAYVAY RKGQNDLELI NITNENSMYR AQARYLVERA DSEIWSFVLS ENNLHRRSLV
DQVIATAVPE STEPDKVSVA VKAFLEADLP GELIELLEKI ILEPSPFSDN GSLQNLLMLT
AAKADKGRLM DYIHQLSEFS ADEIAEMCIS VGLYEEAFEI YKKVNNYIAA VNVLVENIVS
IDRAQEFAER VELPDVWSKV AKAQLDGLRV SDSIESYIRA NDPSNYNEVI ETAIHAGKDE
DLVKYLKMAR KTLREPAIDT ALAFCYARLD QLLELEDFLR STNVADIETS GDKAYAEGYH
QAAKIFYTSI SNWAKLATTL VHLEDYQAAV ECARKANSVK VWKEVNLACV DKKEFRLAQI
CGLNLIVHAE ELQDLVRQYE RHGYFDELIS VLEAGLGLER AHMGMFTELG IALSKYHPDR
VMEHLKLFWS RINIPKMIRA CEEANLWPEL VFLYCHYDEW DNAALAMMER AADAWEHHSF
KDIIVKVANL EIYYRALNFY LQEQPLLLTD LLQVLTSRID VNRVVRIFQT SDNIPLIKPF
LLNVQNQNKR TVNDAINDLL IEEEDYKTLR DSVDNYDNFD AVELAQRLEK HDLIFFRQIA
ANIYRNNKRW EKSIALSKQD KLYKDAIETA AISGKSDVVE ELLRYFVDIG SRECYVGMLY
ACYDLIRPDV ILEMSWRHGL NDFTMPFMIN FLCEQTRTIE MLKKDNEERK SREVTQQKEE
DNTPILGGSR LMLTQGPSTP APAPMAYGQP NGIAPQATGF RPF
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