ID A1CT72_ASPCL Unreviewed; 1095 AA.
AC A1CT72;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Importin beta-4 subunit, putative {ECO:0000313|EMBL:EAW06509.1};
GN ORFNames=ACLA_081990 {ECO:0000313|EMBL:EAW06509.1};
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612 {ECO:0000313|EMBL:EAW06509.1, ECO:0000313|Proteomes:UP000006701};
RN [1] {ECO:0000313|EMBL:EAW06509.1, ECO:0000313|Proteomes:UP000006701}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1
RC {ECO:0000313|Proteomes:UP000006701};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; DS027060; EAW06509.1; -; Genomic_DNA.
DR RefSeq; XP_001267935.1; XM_001267934.1.
DR AlphaFoldDB; A1CT72; -.
DR STRING; 344612.A1CT72; -.
DR EnsemblFungi; EAW06509; EAW06509; ACLA_081990.
DR GeneID; 4700257; -.
DR KEGG; act:ACLA_081990; -.
DR VEuPathDB; FungiDB:ACLA_081990; -.
DR eggNOG; KOG2171; Eukaryota.
DR HOGENOM; CLU_003794_1_1_1; -.
DR OMA; ANACGCV; -.
DR OrthoDB; 22606at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF6; IMPORTIN-4; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006701};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 24..91
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REPEAT 386..424
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 1095 AA; 121688 MW; A99BB45E59D6047E CRC64;
MDQQRFLQQL QIVLNPAQGN VKEATGILQR EFYSKPDSLV LLIQIATGHE DPNLRQLAAV
ESRSLVNKHW VKVQAAQKPQ IREQLLRSTM SEGSSLVRHS IARIISAIAR VDLNDGEWAE
LPNFLIQAGN SGNKDERSVA IYILFTILET LGESLEEKFS DLFALFNKTI RDPESEEVRT
NTLLALGRLA MHLDSDEDVA PVKAFQDLVP SLVAVLKESI DQSQEDRVMQ AFEVFQTLLG
CDPALLTVHL KDLVIFMNEL AANTEVDEDT RTQAISFLMQ CIQYRKLKVQ GMRLGEQLTR
TALHIVTELG DASASDDDIT PARSALGLLD MLAQSLPPSQ VVVPLLHALG QYFNSENPDY
RRAGIMALGM CVEGAPDFIS TQMKDIFPMV LQLLADPEPK VRQASLHAVA RLADDLAEDL
CAEHERIMPL LFKNLASAMQ EYKGEEDGPT IDIMKAGISA IDAVVDGLDE KDVAPYQGEL
VPILHKLFKH PDFRIKGLTA GALGSLASSA GDSFLPYFDE SMHLLQEFAA VKDSEEELDL
RASVTDAMGE MAAAAGAERY QPYVEPLMRA TEEALHLDHS RLKESTYIFW GAMSKVYGEH
FAPFLDGVVK GLFACIEQDE TDLDVSLGEA AKDLVGQEVI IAGRKVKVAS ADDDDEPVGE
DGGIEDVDLD DEDAWDDITA TTPLSLEKEI AVEVIGDLVT HTKSAYLPYF EKTIEEVLPL
AEHPYEGVRR STISTLHRSY AMLFAIAEET GQMAKWQPGL PLQVEPAKEV KKFGEILMTA
TIRMWTEEDD RATVADINRN MAENLRYCGP SLIANETTLQ NLIQMVTDII TKKHPCQIEF
GPEEETLEAG EESSEFDWVV VDTALDVVSG LAAALGESFA ELWKVFEKTI LRYAGSTEAL
ERATAVGVLA ECINGMGGGV TQFTRTFMKL LIHRLGDEDP QTKSNAAYAV GRLVEHSNAD
AELIKEYPTI LSRLESCLQM KVSRLQDNAT GCLSRMILKH RESIPLKDVI PVLVTILPLK
NDYEENDPLY RMICQLYKWE DPTIRELTPQ FLPIFQSVLC GDSDQLEDER RAELIELVKW
LNQMQPGVAP WAEQL
//
