ID A1DJ15_NEOFI Unreviewed; 511 AA.
AC A1DJ15;
DT 23-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 23-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Glycosyl hydrolase family 43 protein {ECO:0000313|EMBL:EAW19372.1};
GN ORFNames=NFIA_093350 {ECO:0000313|EMBL:EAW19372.1};
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117 {ECO:0000313|EMBL:EAW19372.1, ECO:0000313|Proteomes:UP000006702};
RN [1] {ECO:0000313|Proteomes:UP000006702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 /
RC NRRL 181 / WB 181 {ECO:0000313|Proteomes:UP000006702};
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865, ECO:0000256|RuleBase:RU361187}.
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DR EMBL; DS027696; EAW19372.1; -; Genomic_DNA.
DR RefSeq; XP_001261269.1; XM_001261268.1.
DR AlphaFoldDB; A1DJ15; -.
DR EnsemblFungi; EAW19372; EAW19372; NFIA_093350.
DR GeneID; 4587827; -.
DR KEGG; nfi:NFIA_093350; -.
DR VEuPathDB; FungiDB:NFIA_093350; -.
DR eggNOG; ENOG502SI39; Eukaryota.
DR HOGENOM; CLU_009397_6_0_1; -.
DR OMA; FEAPWLM; -.
DR OrthoDB; 5470935at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd08990; GH43_AXH_like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR43772:SF2; BETA-1,4-XYLOSIDASE (EUROFUNG); 1.
DR PANTHER; PTHR43772; ENDO-1,4-BETA-XYLANASE; 1.
DR Pfam; PF04616; Glyco_hydro_43; 1.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361187};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361187};
KW Reference proteome {ECO:0000313|Proteomes:UP000006702};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..511
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002634178"
FT SITE 179
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 511 AA; 55370 MW; 0317966E0D2C0E5A CRC64;
MHMLWSALAF SATALAQVTG SRSIKFISKG NPILSDGSWY SADPAPLVVN KTVYILTGRD
SAAPDENNFI MKQWGMFASS TPNPAGSEWM LYPKVAEPHK VFAWAAPGTS YAAQVVQGRD
GRFYLYAPVT QANSKNEDPF AIGVAVSDSP TGPYVDAHPS GPIISQSVPP PGNSIQNIDP
TVLVDDDGKA YIYFGTFGAL RAYELDADMV TVRSSVTQVN GLTGFFEAPW LMKRKGVYYL
LFAANNAGLD SPCTPTSYHA CIAYATASSP LGPWKFRDVI LPIVSSTTSH PGAIELNGEW
FLVYHTADAN GGGHFRRSIA LDKLNWDDSQ SPPAIRKVVQ TIGPKPPAPP TYNIAPKAVP
SSKYPSGIQY WIKAVNDGII RANPLPPDYW SSYEAEKSRE TSVLTYVWKE PVELNGTSMV
FFADQDAGAN VGVAPPKKWF VEYLDQSSNW QPVVNTTTYA LKVTDTPQVV KFETIRTTSI
RATLIASGSG GQFAGVGVKE WAALATELQK T
//
