ID A1KWY1_STAAU Unreviewed; 211 AA.
AC A1KWY1;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=3-hexulose-6-phosphate synthase {ECO:0000256|ARBA:ARBA00012890};
DE EC=4.1.2.43 {ECO:0000256|ARBA:ARBA00012890};
GN ORFNames=SAP029A_012 {ECO:0000313|EMBL:ACZ58713.1}, SAP039A_038
GN {ECO:0000313|EMBL:ACZ58977.1}, SAP099A_046
GN {ECO:0000313|EMBL:ADA80088.1};
OS Staphylococcus aureus.
OG Plasmid EDINA plasmid {ECO:0000313|EMBL:BAC54543.1},
OG Plasmid pSK156 {ECO:0000313|EMBL:ADA80088.1},
OG Plasmid pWBG746 {ECO:0000313|EMBL:ACZ58713.1}, and
OG Plasmid pWBG747 {ECO:0000313|EMBL:ACZ58977.1}.
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=1280 {ECO:0000313|EMBL:BAC54543.1};
RN [1] {ECO:0000313|EMBL:BAC54543.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=E-1 {ECO:0000313|EMBL:BAC54543.1};
RC PLASMID=EDINA plasmid {ECO:0000313|EMBL:BAC54543.1};
RA Sugai M., Yamaguchi T., Hayashi T., Nakasone K., Takami H.;
RT "Complete nucleotide sequence of Staphylococcus aureus E-1 EDINA plasmid.";
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACZ58713.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=K153N {ECO:0000313|EMBL:ACZ58977.1}, SK1271
RC {ECO:0000313|EMBL:ADA80088.1}, and WB43S
RC {ECO:0000313|EMBL:ACZ58713.1};
RC PLASMID=pSK156 {ECO:0000313|EMBL:ADA80088.1}, pWBG746
RC {ECO:0000313|EMBL:ACZ58713.1}, and pWBG747
RC {ECO:0000313|EMBL:ACZ58977.1};
RA Gill J., Borman J., Shetty J., Hostetler J., Durkin S., Montgomery B.;
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ACZ58713.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=K153N {ECO:0000313|EMBL:ACZ58977.1}, SK1271
RC {ECO:0000313|EMBL:ADA80088.1}, and WB43S
RC {ECO:0000313|EMBL:ACZ58713.1};
RC PLASMID=pSK156 {ECO:0000313|EMBL:ADA80088.1}, pWBG746
RC {ECO:0000313|EMBL:ACZ58713.1}, and pWBG747
RC {ECO:0000313|EMBL:ACZ58977.1};
RA Summers A.O., Shearer J., Wireman J.;
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the condensation of ribulose 5-phosphate with
CC formaldehyde to form 3-hexulose 6-phosphate.
CC {ECO:0000256|ARBA:ARBA00002272}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose
CC 6-phosphate; Xref=Rhea:RHEA:25201, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:58121, ChEBI:CHEBI:58542; EC=4.1.2.43;
CC Evidence={ECO:0000256|ARBA:ARBA00000718};
CC -!- PATHWAY: One-carbon metabolism; formaldehyde assimilation via RuMP
CC pathway; D-fructose 6-phosphate from D-ribulose 5-phosphate and
CC formaldehyde: step 1/2. {ECO:0000256|ARBA:ARBA00005014}.
CC -!- SIMILARITY: Belongs to the HPS/KGPDC family. HPS subfamily.
CC {ECO:0000256|ARBA:ARBA00006350}.
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DR EMBL; GQ900390; ACZ58713.1; -; Genomic_DNA.
DR EMBL; GQ900399; ACZ58977.1; -; Genomic_DNA.
DR EMBL; GQ900448; ADA80088.1; -; Genomic_DNA.
DR EMBL; AP003089; BAC54543.1; -; Genomic_DNA.
DR RefSeq; WP_000776029.1; NZ_WKIV01000061.1.
DR RefSeq; YP_001573923.1; NC_010077.1.
DR RefSeq; YP_006937887.1; NC_013326.1.
DR RefSeq; YP_006938694.1; NC_013348.1.
DR RefSeq; YP_006939352.1; NC_018952.1.
DR AlphaFoldDB; A1KWY1; -.
DR PATRIC; fig|1280.4816.peg.2819; -.
DR UniPathway; UPA00294; UER00434.
DR GO; GO:0043801; F:hexulose-6-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0019647; P:formaldehyde assimilation via ribulose monophosphate cycle; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR CDD; cd04726; KGPDC_HPS; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR017553; 3-hexulose-6-phosphate_synth.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR041710; HPS/KGPDC.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR NCBIfam; TIGR03128; RuMP_HxlA; 1.
DR PANTHER; PTHR35039; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR PANTHER; PTHR35039:SF3; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:ACZ58713.1};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Plasmid {ECO:0000313|EMBL:BAC54543.1}.
FT DOMAIN 2..203
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
SQ SEQUENCE 211 AA; 22334 MW; CD19631357607E3F CRC64;
MKLQLAIDLL DQKEAAKLAQ EVEEFIDIVE IGTPIVINEG LSAVEHMSKS VTNTQVLADL
KIMDAASYEV SQAIKFGADI VTILGVSEDA SIKSAIEEAH NNGKELLVDM IAVQNLEQRA
AELDKMGADY IAVHTGYDLQ AKGVSPLESL RTVKSVISNS KVAVAGGIKP DTIKSVVVEQ
PDLIIVGGGI ANADDPKAAA KKCRDIIDGN A
//
