ID A1SH52_NOCSJ Unreviewed; 462 AA.
AC A1SH52;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=Tryptophanase {ECO:0000313|EMBL:ABL81137.1};
DE EC=4.1.99.1 {ECO:0000313|EMBL:ABL81137.1};
GN OrderedLocusNames=Noca_1624 {ECO:0000313|EMBL:ABL81137.1};
OS Nocardioides sp. (strain ATCC BAA-499 / JS614).
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=196162 {ECO:0000313|EMBL:ABL81137.1, ECO:0000313|Proteomes:UP000000640};
RN [1] {ECO:0000313|Proteomes:UP000000640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA Thompson L.S., Brettin T., Bruce D., Han C., Tapia R., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Mattes T., Gossett J.,
RA Richardson P.;
RT "Complete sequence of chromosome 1 of Nocardioides sp. JS614.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABL81137.1, ECO:0000313|Proteomes:UP000000640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-499 / JS614 {ECO:0000313|Proteomes:UP000000640};
RX PubMed=21551312; DOI=10.1128/JB.05109-11;
RA Coleman N.V., Wilson N.L., Barry K., Brettin T.S., Bruce D.C., Copeland A.,
RA Dalin E., Detter J.C., Del Rio T.G., Goodwin L.A., Hammon N.M., Han S.,
RA Hauser L.J., Israni S., Kim E., Kyrpides N., Land M.L., Lapidus A.,
RA Larimer F.W., Lucas S., Pitluck S., Richardson P., Schmutz J., Tapia R.,
RA Thompson S., Tice H.N., Spain J.C., Gossett J.G., Mattes T.E.;
RT "Genome Sequence of the ethene- and vinyl chloride-oxidizing actinomycete
RT Nocardioides sp. strain JS614.";
RL J. Bacteriol. 193:3399-3400(2011).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR611166-50};
CC -!- SIMILARITY: Belongs to the beta-eliminating lyase family.
CC {ECO:0000256|ARBA:ARBA00009721}.
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DR EMBL; CP000509; ABL81137.1; -; Genomic_DNA.
DR RefSeq; WP_011755084.1; NC_008699.1.
DR AlphaFoldDB; A1SH52; -.
DR STRING; 196162.Noca_1624; -.
DR KEGG; nca:Noca_1624; -.
DR eggNOG; COG3033; Bacteria.
DR HOGENOM; CLU_047223_0_0_11; -.
DR OrthoDB; 9764079at2; -.
DR Proteomes; UP000000640; Chromosome.
DR GO; GO:0009034; F:tryptophanase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR InterPro; IPR011166; Beta-eliminating_lyase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR32325; BETA-ELIMINATING LYASE-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR32325:SF4; TRYPTOPHANASE; 1.
DR Pfam; PF01212; Beta_elim_lyase; 1.
DR PIRSF; PIRSF001386; Trpase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:ABL81137.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR611166-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000000640}.
FT DOMAIN 50..423
FT /note="Aromatic amino acid beta-eliminating lyase/threonine
FT aldolase"
FT /evidence="ECO:0000259|Pfam:PF01212"
FT MOD_RES 260
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR611166-50"
SQ SEQUENCE 462 AA; 50751 MW; DDBEF77BBFA14F6D CRC64;
MDQPFRTIIE PFRIHSVEPM RMTTAEERRT HLAAVDYNLF QLRAEHVLID LLTDSGTGAM
SRDQWAAVQR GDESYAGSPS YFVFRDAVRR LFDFEHIIPV HQGRAAERIL FSVLGGAGKV
IPNNTHFDTT RANIEATGAE AVDLVIAEGR DPRSDHPFKG NMDLAALEQL LEAHADDVPC
VMVTITNNSG GGQPVSLANL RGVRALCDRF GKPLFLDACR FAENAWFIRE REAGQGERDV
VDIIRDVTGL ADGVTMSAKK DPLGNIGGWL ALADDDLAAQ CRNIVILTEG FPTYGGLAGR
DLEALAQGLA EVVQHDYLRY RIGSTAYLGR ALAERGVPVL SPFGGHAIYL DARALLPHLD
PLEYPGQAVA VALYEIGGIR SCEIGTVMFG RHPDGSEQPA AMDLVRLAIP RRTYTQSHID
YVIEVCERIL DRASDLPGYR IVEEPPALRH FTARFAPLGR TA
//
