ID   A1THX9_MYCVP            Unreviewed;       737 AA.
AC   A1THX9;
DT   06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   06-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   OrderedLocusNames=Mvan_6025 {ECO:0000313|EMBL:ABM16779.1};
OS   Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 /
OS   KCTC 9966 / NRRL B-24157 / PYR-1) (Mycobacterium vanbaalenii).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=350058 {ECO:0000313|EMBL:ABM16779.1, ECO:0000313|Proteomes:UP000009159};
RN   [1] {ECO:0000313|EMBL:ABM16779.1, ECO:0000313|Proteomes:UP000009159}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 /
RC   PYR-1 {ECO:0000313|Proteomes:UP000009159};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Singan V., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Anderson I.J., Miller C., Richardson P.;
RT   "Complete sequence of Mycobacterium vanbaalenii PYR-1.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; CP000511; ABM16779.1; -; Genomic_DNA.
DR   RefSeq; WP_011783123.1; NZ_JACKSD010000057.1.
DR   AlphaFoldDB; A1THX9; -.
DR   STRING; 350058.Mvan_6025; -.
DR   KEGG; mva:Mvan_6025; -.
DR   eggNOG; COG0210; Bacteria.
DR   HOGENOM; CLU_023846_0_0_11; -.
DR   Proteomes; UP000009159; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF68; DNA HELICASE; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000009159}.
FT   DOMAIN          255..579
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   REGION          109..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         276..283
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   737 AA;  80295 MW;  0DCDA39E941FD2DF CRC64;
     MANLVIASNS KGMSKLDGSV KNKVYDFFEK LNADDTSPKL HIEPMKGAID PRVRTGRVDL
     YWRAILFRID DKSSGTTYIY MGTWPHDDAI KLAERATLRV NPINGTLEGL IGEAPSPETG
     GPQTAPPVTA KPEPSYLAGF GYTQSDLTDG LGIDSALAAS AMAAPDEAAL LEAAAAGLEW
     EGSALLDLAT GISIDTIREK HGFTDEPVDT TGDEDKRIIE ALDRPASKMQ FAFIEDDEEL
     RRVIEGGDFA AWRTFLHPEQ RKYVDLDFSG AFRLSGGAGT GKTVVAIHRA RRLARDNPNA
     RIILTTFNAT LAQGLKADLV ALDPNVRIAE KPGDPGVYVG GIDALGRAVL DRSRDVLTAA
     GKRIFGSGAM EFSAKRTSAD AVWREVAQSV ESGLDAKLAT PAFLETEYVA VVLANRITTL
     EQYAKVARPG RGVRLSRQQR IAVWKLVEAF RRQSQMDETL SFPEILALAA EALRIKSETD
     GTFLADHVLV DEAQDLHATH WALLRALVSE GANDLFIAED SHQRIYGSPI VLSRFGIKIV
     GRSRRLTLNY RTTAQNLHFA VSVLSGAEYT DLEQAEESTS EYRSARNGPA PELIPCTDMA
     DELEAVATKV KAWLTEDGVE PESIAILTRS QEERDRFVRG LGERGVTARS LDKSAATPGQ
     PLVMTMHRAK GMEFSRVILA GADDKHVPLP ATLRSVPDEE KGEAMLRERS LLYVASSRAR
     DALVVTWSGK KSELLGE
//