ID A1XD07_CTEPI Unreviewed; 231 AA.
AC A1XD07;
DT 06-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 06-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:ABC70012.1};
OS Ctenophorus pictus (Painted dragon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Acrodonta; Agamidae; Amphibolurinae; Ctenophorus.
OX NCBI_TaxID=180001 {ECO:0000313|EMBL:ABC70012.1};
RN [1] {ECO:0000313|EMBL:ABC70012.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ABTC53422 {ECO:0000313|EMBL:ABC70012.1};
RX AGRICOLA=IND43999332;
RA Hugall A.F., Foster R., Hutchinson M., Lee M.S.Y.;
RT "Phylogeny of Australasian agamid lizards based on nuclear and
RT mitochondrial genes: implications for morphological evolution and
RT biogeography.";
RL Biol. J. Linn. Soc. Lond. 93:343-358(2008).
CC -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC located either in the central nervous system or directly connected to
CC it. {ECO:0000256|ARBA:ARBA00002323, ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; DQ340718; ABC70012.1; -; Genomic_DNA.
DR AlphaFoldDB; A1XD07; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001789-1};
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 122..229
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT DISULFID 130..197
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 175..226
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT DISULFID 185..228
FT /evidence="ECO:0000256|PIRSR:PIRSR001789-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABC70012.1"
FT NON_TER 231
FT /evidence="ECO:0000313|EMBL:ABC70012.1"
SQ SEQUENCE 231 AA; 26026 MW; 048628B0BAD80BC4 CRC64;
ISYFSCMKAA PMKEVSLRGQ GSLAYPGLRT QGHLEDLGGP NEATRGLTSL ADTFEHVIEE
LLDEQAIQPS KENKDADLYS SRVMLSSQVP LEPPLLFLLE EYKNYLDAAN MSMRVRRHSD
PARRGELSVC DSTSEWVTAA EKKTAVDMSG ATVTVLEKVP VPKGQLKQYF YETKCNSKGY
TKEGCRGIDK RYWNSQCRTT QSYVRALTMD NKKRVGWRFI RIDTSCVCTL T
//
