ID A2AE50_HUMAN Unreviewed; 122 AA.
AC A2AE50;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE RecName: Full=Tripartite motif-containing protein 26 {ECO:0000256|ARBA:ARBA00039446};
DE AltName: Full=Zinc finger protein 173 {ECO:0000256|ARBA:ARBA00041435};
DE Flags: Fragment;
GN Name=TRIM26 {ECO:0000313|Ensembl:ENSP00000400920.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000400920.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000400920.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2] {ECO:0000313|Ensembl:ENSP00000400920.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL662782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL662832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL671855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL844220; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL845450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX248419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927189; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX927221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR388382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR788282; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteomicsDB; 395; -.
DR Antibodypedia; 26253; 150 antibodies from 22 providers.
DR Ensembl; ENST00000427612.5; ENSP00000405526.1; ENSG00000137313.15.
DR Ensembl; ENST00000429583.5; ENSP00000393827.1; ENSG00000226060.7.
DR Ensembl; ENST00000431641.5; ENSP00000388005.1; ENSG00000231002.7.
DR Ensembl; ENST00000434785.5; ENSP00000400920.1; ENSG00000234127.9.
DR Ensembl; ENST00000435387.5; ENSP00000405923.1; ENSG00000230230.7.
DR Ensembl; ENST00000440149.1; ENSP00000403887.1; ENSG00000228881.7.
DR Ensembl; ENST00000445457.1; ENSP00000403765.1; ENSG00000231641.9.
DR Ensembl; ENST00000447942.5; ENSP00000396089.1; ENSG00000234046.7.
DR UCSC; uc063mqp.1; human.
DR HGNC; HGNC:12962; TRIM26.
DR VEuPathDB; HostDB:ENSG00000234127; -.
DR GeneTree; ENSGT00940000158668; -.
DR OMA; PFFWLNW; -.
DR ChiTaRS; TRIM26; human.
DR Proteomes; UP000005640; Chromosome 6.
DR Bgee; ENSG00000234127; Expressed in granulocyte and 106 other cell types or tissues.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR PANTHER; PTHR24103:SF369; TRIPARTITE MOTIF-CONTAINING PROTEIN 26; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|EPD:A2AE50,
KW ECO:0007829|MaxQB:A2AE50};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 16..57
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 97..122
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT NON_TER 122
FT /evidence="ECO:0000313|Ensembl:ENSP00000400920.1"
SQ SEQUENCE 122 AA; 13993 MW; 11EF987FEA8C7D13 CRC64;
MATSAPLRSL EEEVTCSICL DYLRDPVTID CGHVFCRSCT TDVRPISGSR PVCPLCKKPF
KKENIRPVWQ LASLVENIER LKVDKGRQPG EVTREQQDAK LCERHREKLH YYCEDDGKLL
CV
//
