ID A2ALX7_MOUSE Unreviewed; 385 AA.
AC A2ALX7;
DT 05-FEB-2008, integrated into UniProtKB/TrEMBL.
DT 05-FEB-2008, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE SubName: Full=Rho GTPase activating protein 6 {ECO:0000313|Ensembl:ENSMUSP00000107757.2};
GN Name=Arhgap6 {ECO:0000313|Ensembl:ENSMUSP00000107757.2,
GN ECO:0000313|MGI:MGI:1196332};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000107757.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000107757.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000107757.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000107757.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000107757.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A2ALX7; -.
DR SMR; A2ALX7; -.
DR MaxQB; A2ALX7; -.
DR ProteomicsDB; 359555; -.
DR Antibodypedia; 23727; 70 antibodies from 21 providers.
DR Ensembl; ENSMUST00000112129.8; ENSMUSP00000107757.2; ENSMUSG00000031355.17.
DR UCSC; uc009uxn.2; mouse.
DR AGR; MGI:1196332; -.
DR MGI; MGI:1196332; Arhgap6.
DR VEuPathDB; HostDB:ENSMUSG00000031355; -.
DR GeneTree; ENSGT00940000153904; -.
DR ChiTaRS; Arhgap6; mouse.
DR Proteomes; UP000000589; Chromosome X.
DR Bgee; ENSMUSG00000031355; Expressed in lateral septal nucleus and 206 other cell types or tissues.
DR ExpressionAtlas; A2ALX7; baseline and differential.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037863; RHOGAP6/36.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR12635:SF6; RHO GTPASE-ACTIVATING PROTEIN 6; 1.
DR PANTHER; PTHR12635; RHO-GTPASE-ACTIVATING PROTEIN 6 FAMILY MEMBER; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|MaxQB:A2ALX7,
KW ECO:0007829|PeptideAtlas:A2ALX7};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 221..385
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 142..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 385 AA; 43803 MW; 827CC396FCF74C9F CRC64;
MGDPSYSEKP RLHYAGDFTW NSMSGRSVRL RSVPIQSLSE LERARLQEVA FYQLQQDCDL
GCQITIPKDG QKRKKSLRKK LDSLGKEKNK DKEFIPQAFG MPLSQVIAND RAYKLKQDLQ
REEQKDASSD FVSSLLPFGN KKQNKELSSS NSSLSSTSET PNESTSPNTP EPAPRARRRG
AMSVDSITDL DDNQSRLLEA LQLSLPAEAQ SKKEKARDKK LSLNPIYRQV PRLVDSCCQH
LEKHGLQTVG IFRVGSSKKR VRQLREEFDR GVDVCLEEEH SVHDVAALLK EFLRDMPDPL
LTRELYTAFI NTLLLEPEEQ LGTLQLLIYL LPPCNCDTLH RLLQFLSIVA RHADDNVSKD
GQEVCCYKES VFLWIVHPCF CYCSI
//
