ID A2AWU3_DANRE Unreviewed; 457 AA.
AC A2AWU3; A0A8M2BD36;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=Olfactomedin 1a {ECO:0000313|Ensembl:ENSDARP00000115558, ECO:0000313|RefSeq:XP_005165655.1};
GN Name=olfm1a {ECO:0000313|Ensembl:ENSDARP00000115558,
GN ECO:0000313|RefSeq:XP_005165655.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040718-194};
GN Synonyms=zgc:111962 {ECO:0000313|RefSeq:XP_005165655.1}, zgc:92854
GN {ECO:0000313|RefSeq:XP_005165655.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000115558};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000115558, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000115558};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000115558}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000115558};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005165655.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005165655.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR EMBL; AL929048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL954815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005165655.1; XM_005165598.4.
DR Ensembl; ENSDART00000134241; ENSDARP00000115558; ENSDARG00000018270.
DR Ensembl; ENSDART00000134241.3; ENSDARP00000115558.1; ENSDARG00000018270.11.
DR GeneID; 436764; -.
DR AGR; ZFIN:ZDB-GENE-040718-194; -.
DR CTD; 436764; -.
DR ZFIN; ZDB-GENE-040718-194; olfm1a.
DR OrthoDB; 2876896at2759; -.
DR Proteomes; UP000000437; Chromosome 5.
DR Bgee; ENSDARG00000018270; Expressed in brain and 30 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0007409; P:axonogenesis; IMP:ZFIN.
DR GO; GO:0060041; P:retina development in camera-type eye; IMP:ZFIN.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR022082; Noelin_dom.
DR InterPro; IPR003112; Olfac-like_dom.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR PANTHER; PTHR23192:SF34; NOELIN; 1.
DR PANTHER; PTHR23192; OLFACTOMEDIN-RELATED; 1.
DR Pfam; PF12308; Noelin-1; 1.
DR Pfam; PF02191; OLF; 1.
DR SMART; SM00284; OLF; 1.
DR SUPFAM; SSF50969; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR PROSITE; PS51132; OLF; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00446}; Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..457
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041116466"
FT DOMAIN 198..450
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT COILED 66..114
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 150..196
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 199..381
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ SEQUENCE 457 AA; 52411 MW; 8BB211F2971F6EB2 CRC64;
MQPANKLLSL TLLVLMGTEL TQVLPANPEE SWQVYSSAQD SEGRCVCTVV APQQTMCSRD
ARTKQLRQLL EKVQNMTQSI QNLDQRTQKD LQYVQRMEVQ LRGLETKFKQ VEESHKQNIA
KQYKAIKAKM EELRPMIPVL EEYKADAKLV MQFKEEVKNL TSVLSELQEE IGAFDYEELH
NRVSNLEERL RACMQKLACG KLTGISDAIT IKTSGSRYGS WMTDPLAPDG DTRVWYMDGY
HNNRFVREYK SMADFMYSDN FTSHRLPHPW SGTGQVVYNG SIYFNKFQSN TIIKFDFKTA
TISKSGQLDY AGFNNRYHYS WGGHSDIDLM VDEGGLWAIY ATNQNAGNIV ISKLNPATLQ
IVKSYTTNHP KRSAGEAFMI CGTLYVTNGY SGGTKVYYAF HTNSSTYEYI DIPLQNKYSH
ISMLDYNPRD RALYAWNNGH QVLYNVTLFH VIRSEEL
//
