ID A2BGK3_DANRE Unreviewed; 106 AA.
AC A2BGK3; A0A8M1NHL2;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=SH2 domain-containing 1A duplicate a {ECO:0000313|Ensembl:ENSDARP00000122911, ECO:0000313|RefSeq:NP_001108163.1};
GN Name=sh2d1aa {ECO:0000313|Ensembl:ENSDARP00000122911,
GN ECO:0000313|RefSeq:NP_001108163.1,
GN ECO:0000313|ZFIN:ZDB-GENE-060526-212};
GN Synonyms=si:dkey-13n15.6 {ECO:0000313|RefSeq:NP_001108163.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000122911};
RN [1] {ECO:0000313|RefSeq:NP_001108163.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001108163.1};
RX PubMed=23174758; DOI=10.1016/j.mce.2012.11.009;
RA Wong M.K., Takei Y.;
RT "Angiotensin AT2 receptor activates the cyclic-AMP signaling pathway in
RT eel.";
RL Mol. Cell. Endocrinol. 365:292-302(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000122911, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000122911};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000122911}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000122911};
RG Ensembl;
RL Submitted (SEP-2013) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:NP_001108163.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001108163.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; BX470224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001108163.1; NM_001114691.1.
DR STRING; 7955.ENSDARP00000122911; -.
DR PaxDb; 7955-ENSDARP00000122911; -.
DR Ensembl; ENSDART00000144519; ENSDARP00000122911; ENSDARG00000095348.
DR Ensembl; ENSDART00000144519.2; ENSDARP00000122911.1; ENSDARG00000095348.2.
DR GeneID; 797046; -.
DR KEGG; dre:797046; -.
DR AGR; ZFIN:ZDB-GENE-060526-212; -.
DR CTD; 797046; -.
DR ZFIN; ZDB-GENE-060526-212; sh2d1aa.
DR eggNOG; KOG0565; Eukaryota.
DR HOGENOM; CLU_125532_1_0_1; -.
DR OMA; HKHINTS; -.
DR OrthoDB; 3945625at2759; -.
DR PhylomeDB; A2BGK3; -.
DR TreeFam; TF343096; -.
DR Proteomes; UP000000437; Chromosome 5.
DR Bgee; ENSDARG00000095348; Expressed in retina and 8 other cell types or tissues.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR46051:SF1; IPPC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46051; SH2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 6..101
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 106 AA; 11914 MW; CE10E788916C656C CRC64;
MEDLAEYHGS ISKKQAEDIL CSTGRDGSYL IRDSLSSAGA YCVCVLCDGW VYTYRIFNKG
GLWTIEMAPG MKERLFRNVS NLIAAFKMPD QGITFPLLYP VNKPKH
//
