ID A2BY42_PROM5 Unreviewed; 280 AA.
AC A2BY42;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE SubName: Full=UDP-N-acetylglucosamine acyltransferase {ECO:0000313|EMBL:ABM72703.1};
DE EC=2.3.1.129 {ECO:0000313|EMBL:ABM72703.1};
GN Name=lpxA {ECO:0000313|EMBL:ABM72703.1};
GN OrderedLocusNames=P9515_14961 {ECO:0000313|EMBL:ABM72703.1};
OS Prochlorococcus marinus (strain MIT 9515).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales;
OC Prochlorococcaceae; Prochlorococcus.
OX NCBI_TaxID=167542 {ECO:0000313|EMBL:ABM72703.1, ECO:0000313|Proteomes:UP000001589};
RN [1] {ECO:0000313|EMBL:ABM72703.1, ECO:0000313|Proteomes:UP000001589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MIT 9515 {ECO:0000313|EMBL:ABM72703.1,
RC ECO:0000313|Proteomes:UP000001589};
RX PubMed=18159947; DOI=10.1371/journal.pgen.0030231;
RA Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S.,
RA Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M.,
RA Richardson P., Chisholm S.W.;
RT "Patterns and implications of gene gain and loss in the evolution of
RT Prochlorococcus.";
RL PLoS Genet. 3:2515-2528(2007).
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DR EMBL; CP000552; ABM72703.1; -; Genomic_DNA.
DR RefSeq; WP_011820799.1; NC_008817.1.
DR AlphaFoldDB; A2BY42; -.
DR STRING; 167542.P9515_14961; -.
DR GeneID; 60201204; -.
DR KEGG; pmc:P9515_14961; -.
DR eggNOG; COG1043; Bacteria.
DR HOGENOM; CLU_061249_0_0_3; -.
DR OrthoDB; 9807278at2; -.
DR Proteomes; UP000001589; Chromosome.
DR GO; GO:0031470; C:carboxysome; IEA:UniProt.
DR GO; GO:0008780; F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0043886; F:structural constituent of carboxysome shell; IEA:UniProt.
DR GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd03351; LbH_UDP-GlcNAc_AT; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR029098; Acetyltransf_C.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR010137; Lipid_A_LpxA.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR NCBIfam; TIGR01852; lipid_A_lpxA; 1.
DR PANTHER; PTHR43480; ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR43480:SF1; ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF13720; Acetyltransf_11; 1.
DR Pfam; PF00132; Hexapep; 1.
DR PIRSF; PIRSF000456; UDP-GlcNAc_acltr; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000313|EMBL:ABM72703.1};
KW Lipid A biosynthesis {ECO:0000256|ARBA:ARBA00022556};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ABM72703.1}.
FT DOMAIN 188..266
FT /note="UDP N-acetylglucosamine O-acyltransferase C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF13720"
SQ SEQUENCE 280 AA; 30228 MW; 1235F0D56553AD40 CRC64;
MEIKNTKRNP DFRGARVHPN AVVDSSAELH DGVSIASGAI VGPNVIIESG TKIGSNAVIE
GKTKIGKDNK VFPNVFIGLE PQDLKYQGAS TEVIIGDNNT FRECVTINKA TDEGEKTIIG
NNNLLMAYTH IGHNCVLGNG IVLSNSVQVA GHVKIEDNAI IGGCLGIHQF VHVGYLAMIG
GMTRVDRDVP PFCLAEGHPG RLRGLNRVGI KRSGLMENEE FDLKLLQNTW NLLFKSNDVI
SISLGMAMKG KLDISSAKLC EFVKDSISKQ RRGPMPSVNL
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