ID A2IBA6_HUMAN Unreviewed; 417 AA.
AC A2IBA6;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=Lipase H {ECO:0000313|EMBL:ABM67094.1, ECO:0000313|Ensembl:ENSP00000396384.2};
GN Name=LIPH {ECO:0000313|Ensembl:ENSP00000396384.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ABM67094.1};
RN [1] {ECO:0000313|Ensembl:ENSP00000396384.2, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [2] {ECO:0000313|EMBL:ABM67094.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17095700; DOI=10.1126/science.1133276;
RA Kazantseva A., Goltsov A., Zinchenko R., Grigorenko A.P., Abrukova A.V.,
RA Moliaka Y.K., Kirillov A.G., Guo Z., Lyle S., Ginter E.K., Rogaev E.I.;
RT "Human hair growth deficiency is linked to a genetic defect in the
RT phospholipase gene LIPH.";
RL Science 314:982-985(2006).
RN [3] {ECO:0000313|Ensembl:ENSP00000396384.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|RuleBase:RU004262}.
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DR EMBL; AC099661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; EF186228; ABM67094.1; -; mRNA.
DR RefSeq; XP_016861341.1; XM_017005852.1.
DR ESTHER; human-LIPH; Phospholipase.
DR ProteomicsDB; 438; -.
DR Antibodypedia; 33838; 99 antibodies from 23 providers.
DR DNASU; 200879; -.
DR Ensembl; ENST00000424591.6; ENSP00000396384.2; ENSG00000163898.10.
DR GeneID; 200879; -.
DR UCSC; uc010hyh.4; human.
DR CTD; 200879; -.
DR HGNC; HGNC:18483; LIPH.
DR VEuPathDB; HostDB:ENSG00000163898; -.
DR GeneTree; ENSGT00940000156285; -.
DR OrthoDB; 3428256at2759; -.
DR BioGRID-ORCS; 200879; 9 hits in 1151 CRISPR screens.
DR ChiTaRS; LIPH; human.
DR GenomeRNAi; 200879; -.
DR Proteomes; UP000005640; Chromosome 3.
DR Bgee; ENSG00000163898; Expressed in buccal mucosa cell and 132 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd00707; Pancreat_lipase_like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR013818; Lipase.
DR InterPro; IPR016272; Lipase_LIPH.
DR InterPro; IPR033906; Lipase_N.
DR InterPro; IPR000734; TAG_lipase.
DR PANTHER; PTHR11610; LIPASE; 1.
DR PANTHER; PTHR11610:SF12; LIPASE MEMBER H; 1.
DR Pfam; PF00151; Lipase; 1.
DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 2.
DR PRINTS; PR00821; TAGLIPASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:A2IBA6,
KW ECO:0007829|ProteomicsDB:A2IBA6};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..417
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014565290"
FT DOMAIN 34..177
FT /note="Lipase"
FT /evidence="ECO:0000259|Pfam:PF00151"
SQ SEQUENCE 417 AA; 47202 MW; B3AEAF22887D54F3 CRC64;
MLRFYLFISL LCLSRSDAEE TCPSFTRLSF HSAVVGTGLN VRLMLYTRKN LTCAQTINSS
AFGNLNVTKK TTFIVHGFRP TGSPPVWMDD LVKGLLSVED MNVVVVDWNR GATTLIYTHA
SSKTRKVAMV LKEFIDQMLA EGASLDDIYM IGVSLGAHIS GFVGEMYDGW LGRITALGYK
EPLGNIDFYP NGGLDQPGCP KTILGGFQYF KCDHQRSVYL YLSSLRESCT ITAYPCDSYQ
DYRNGKCVSC GTSQKESCPL LGYYADNWKD HLRGKDPPMT KAFFDTAEES PFCMYHYFVD
IITWNKNVRR GDITIKLRDK AGNTTESKIN HEPTTFQKYH QVSLLARFNQ DLDKVAAISL
MFSTGSLIGP RYKLRILRMK LRSLAHPERP QLCRYDLVLM ENVETVFQPI LCPELQL
//
