ID A2IT63_ANAPL Unreviewed; 153 AA.
AC A2IT63;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Insulin like growth factor 1 {ECO:0000313|Ensembl:ENSAPLP00020026579.1};
DE SubName: Full=Insulin-like growth factor-I {ECO:0000313|EMBL:BAB69036.1};
GN Name=IGF-I {ECO:0000313|EMBL:BAB69036.1};
GN Synonyms=IGF1 {ECO:0000313|Ensembl:ENSAPLP00020026579.1};
OS Anas platyrhynchos (Mallard) (Anas boschas).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Anseriformes; Anatidae;
OC Anatinae; Anas.
OX NCBI_TaxID=8839 {ECO:0000313|EMBL:BAB69036.1};
RN [1] {ECO:0000313|EMBL:BAB69036.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Cherry valley {ECO:0000313|EMBL:BAB69036.1};
RA Kansaku N., Yagi E., Nakada A., Okabayashi H., Guemene D., Zadworny D.;
RT "Molecular cloning of insulin-like growth factor-I complimentary DNA and
RT promoter region in the domestic duck (Anas platyrhynchos).";
RL Anim. Sci. J. 74:277-282(2003).
RN [2] {ECO:0000313|Ensembl:ENSAPLP00020026579.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; AB061721; BAB69036.1; -; mRNA.
DR RefSeq; XP_005022610.1; XM_005022553.2.
DR SMR; A2IT63; -.
DR Ensembl; ENSAPLT00020028626.1; ENSAPLP00020026579.1; ENSAPLG00020018102.1.
DR GeneID; 101793597; -.
DR KEGG; apla:101793597; -.
DR CTD; 3479; -.
DR HOGENOM; CLU_123939_0_0_1; -.
DR OMA; NECCFQS; -.
DR OrthoDB; 5402912at2759; -.
DR Proteomes; UP000694400; Chromosome 1.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0046676; P:negative regulation of insulin secretion; ISS:AgBase.
DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; ISS:AgBase.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; ISS:AgBase.
DR GO; GO:1990418; P:response to insulin-like growth factor stimulus; ISS:AgBase.
DR CDD; cd04368; IlGF; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR022341; IGF-I.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR022350; Insulin-like_growth_factor.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR46845; INSULIN-LIKE GROWTH FACTOR I; 1.
DR PANTHER; PTHR46845:SF1; INSULIN-LIKE GROWTH FACTOR I; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR02002; INSLNLIKEGF.
DR PRINTS; PR02005; INSLNLIKEGF1.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR622350-50};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..109
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
FT REGION 119..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..138
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 54..96
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 66..109
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
FT DISULFID 95..100
FT /evidence="ECO:0000256|PIRSR:PIRSR622350-50"
SQ SEQUENCE 153 AA; 17295 MW; 9195AD9D60164072 CRC64;
MEKINSLSTQ LVKCCFCDFL KVKMHTVSYI HFFYLGLCLL TLTSSVAAGP ETLCGAELVD
ALQFVCGDRG FYFSKPTGYG SSSRRLHHKG IVDECCFQSC DLRRLEMYCA PIKPPKSARS
VRAQRHTDMP KAQKEVHLKN TSRGNTGNRN YRM
//
