ID A2JNH2_HUMAN Unreviewed; 390 AA.
AC A2JNH2;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE SubName: Full=MLL/GAS7 fusion protein {ECO:0000313|EMBL:AAG26331.2};
DE Flags: Fragment;
GN Name=MLL/GAS7 {ECO:0000313|EMBL:AAG26331.2};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAG26331.2};
RN [1] {ECO:0000313|EMBL:AAG26331.2}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10706619; DOI=10.1073/pnas.050397097;
RA Megonigal M.D., Cheung N.-K.V., Rappaport E.F., Nowell P.C., Wilson R.B.,
RA Jones D.H., Addya K., Leonard D.G.B., Kushner B.H., Williams T.M.,
RA Lange B.J., Felix C.A.;
RT "Detection of leukemia-associated MLL-GAS7 translocation early during
RT chemotherapy with DNA topoisomerase II inhibitors.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:2814-2819(2000).
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DR EMBL; AF231997; AAG26331.2; -; mRNA.
DR AlphaFoldDB; A2JNH2; -.
DR PeptideAtlas; A2JNH2; -.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23065:SF57; GROWTH ARREST-SPECIFIC PROTEIN 7; 1.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00397; WW; 1.
DR Pfam; PF16623; WW_FCH_linker; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils}.
FT DOMAIN 112..145
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 231..390
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT REGION 1..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 361..388
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 61..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAG26331.2"
FT NON_TER 390
FT /evidence="ECO:0000313|EMBL:AAG26331.2"
SQ SEQUENCE 390 AA; 43590 MW; 2903456795042886 CRC64;
TTGPPRKEVP KTTPSEPKKK QPPPPESGPE QSKQKKVAPR PSIPVKQKPK EKEKPPPVNK
QENAGTLNIL STLSNGNSSK QKIPADGVHR IRVDFKKPGM VPPPPGEESQ TVILPPGWQS
YLSPQGRRYY VNTTTNETTW ERPSSSPGIP ASPGSHRSSL PPTVNGYHAS GTPAHPPETA
HMSVRKSTGD SQNLGSSSPS KKQSKENTIT INCVTFPHPD TMPEQQLLKP TEWSYCDYFW
ADKKDPQGNG TVAGFELLLQ KQLKGKQMQK EMSEFIRERI KIEEDYAKNL AKLSQNSLAS
QEEGSLGEAW AQVKKSLADE AEVHLKFSAK LHSEVEKPLM NFRENFKKDM KKCDHHIADL
RKQLASRYAS VEKARKALTE RQRDLEMKTR
//
