ID A2N3K1_MOUSE Unreviewed; 111 AA.
AC A2N3K1;
DT 20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT 20-FEB-2007, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=VA11.1 protein {ECO:0000313|EMBL:AAA93055.1};
DE Flags: Fragment;
GN Name=VA11.1 {ECO:0000313|EMBL:AAA93055.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAA93055.1};
RN [1] {ECO:0000313|EMBL:AAA93055.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DBA/1LacJ {ECO:0000313|EMBL:AAA93055.1};
RC TISSUE=Lymph node {ECO:0000313|EMBL:AAA93055.1};
RX PubMed=7594614;
RA Rosloniec E.F., Brand D.D., Whittington K.B., Stuart J.M., Ciubotaru M.,
RA Ward E.S.;
RT "Vaccination with a recombinant V alpha domain of a TCR prevents the
RT development of collagen-induced arthritis.";
RL J. Immunol. 155:4504-4511(1995).
CC -!- SUBUNIT: Alpha-beta TR is a heterodimer composed of an alpha and beta
CC chain; disulfide-linked. The alpha-beta TR is associated with the
CC transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR
CC or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in
CC the endoplasmic reticulum where a single alpha-beta TR heterodimer
CC associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer
CC and one CD247 homodimer forming a stable octameric structure. CD3D-CD3E
CC and CD3G-CD3E heterodimers preferentially associate with TR alpha and
CC TR beta chains, respectively. The association of the CD247 homodimer is
CC the last step of TcR assembly in the endoplasmic reticulum and is
CC required for transport to the cell surface.
CC {ECO:0000256|ARBA:ARBA00038651}.
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DR EMBL; L47342; AAA93055.1; -; Genomic_DNA.
DR AlphaFoldDB; A2N3K1; -.
DR CDD; cd04983; IgV_TCR_alpha; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR19339:SF9; -; 1.
DR PANTHER; PTHR19339; T CELL RECEPTOR ALPHA VARIABLE 39; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
FT DOMAIN 2..91
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAA93055.1"
FT NON_TER 111
FT /evidence="ECO:0000313|EMBL:AAA93055.1"
SQ SEQUENCE 111 AA; 12278 MW; 6BF54FC4B8F05417 CRC64;
GDQVEQSPSA LSLHEGTDSA LRCNFTTTMR SVQWFRQNSR GSLISLFYLA SGTKENGRLK
SAFDSKERRY STLHIRDAQL EDSGTYFCAA EASSGSWQLI FGSGTQLTVM P
//
