ID A2Q861_ASPNC Unreviewed; 2116 AA.
AC A2Q861;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Contig An01c0080, genomic contig {ECO:0000313|EMBL:CAK43684.1};
GN ORFNames=An01g03180 {ECO:0000313|EMBL:CAK43684.1};
OS Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011 {ECO:0000313|EMBL:CAK43684.1, ECO:0000313|Proteomes:UP000006706};
RN [1] {ECO:0000313|EMBL:CAK43684.1, ECO:0000313|Proteomes:UP000006706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892
RC {ECO:0000313|Proteomes:UP000006706};
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA van Ooyen A.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; AM269955; CAK43684.1; -; Genomic_DNA.
DR RefSeq; XP_001388752.1; XM_001388715.2.
DR EnsemblFungi; CAK43684; CAK43684; An01g03180.
DR GeneID; 4978408; -.
DR KEGG; ang:An01g03180; -.
DR VEuPathDB; FungiDB:An01g03180; -.
DR HOGENOM; CLU_000595_0_1_1; -.
DR OrthoDB; 8258at2759; -.
DR Proteomes; UP000006706; Chromosome 2R.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08679; C2_DOCK180_related; 1.
DR CDD; cd11684; DHR2_DOCK; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF10; MYOBLAST CITY, ISOFORM B; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000006706};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 7..88
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 622..803
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1446..1856
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 151..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1843..2087
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1915..1947
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2002..2016
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2017..2087
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2116 AA; 236048 MW; DD1785E1EADD9FDE CRC64;
MPWRPLPRIA FAVAIYPFQP TTPADLPLEL GDELYIIEQG GANGEWCRGY LVAPPSLLAG
LTSSKGQTLE ARVFSGIFPR NCVEIREVLG DGEKTITNGD RSSVAFTAVP EGDVRHSMAS
FQDDDHAFGE VSSVVIAKKG KPSQIFIQRL DEDGRGSPAS PRSPQNFLRT NSTPLAPINV
APRDPDAPKP AAPVPMLKIG DETPTSLSEP LVDEIASCLR EWHSTNLHQL LLSRQYVTVE
EMTKIVEELD FARRQLLYNV LTAQEKDALR QEVVWKLVRG NKALGGEIIV RDPQQRGRLL
TGEDSAVELA RLQSEMSMLD SSPMQQSDAA ALHHLMLEVN AVSGHAPGPV TLAVYLCSQS
ETGALTPLSE TYVLDIPSPE KFASMGQSAK LKTLFTDLSS TDIGDNAANG PRLYMVVMVR
APETTSVVSA AAQPRTSISR DSSSGTKQQN GINQSVKGSL RTRRSMMWTS KPRGIQSPEQ
GKEPSKAAPP SSGSNASAKE KASSQPVKES TQLRTVGVGF LEISQILRQE KDAEQVINIW
SPSEDSEDKE GRDDGFDGVV RTLLPSPTGK YVRSQRAARL HFHLYPYVDP DADSLVRKNP
TSLHNVVQTK RMGFSQAPTK PRSDIYVTIC HATFPPEALL SHPQSGQVPV PGHTGLHNLQ
LTLEVRTSSG ARVDRCVFSA SNHAAQTAWR TTVADRGAPW NQTIRLNIPT DQIPGSHLIM
SIADAPEFPF ALAWMPLWDN QAFMRDGPHS LLLHAYDKCT SNIENGKGAY LSLPWSSLGK
NESAKDEAIT GPLATLRLDT HLCSTEYSQD QVILSLLNWR ERPVNEVLDT LKRVLFVPEI
EIVKQLSSVL DSLFGILVEN AGNEEYEDLI FNDLVTVLGI VHDRRFNLGP LVDHYADNQF
NFPFATPCLV RSYLRLLQAS SDAQQSRNLR ATFKVGRHVL KFIINARLQQ KAKEEGIGIT
RVQSTFNRDL HTIFKSLEAL MKNPSPAMVG NKTLVVQHFH TWLPELSKVL SRDETIMIAL
SFIDSCKDVT GMLILYKLVL IQHYTRLEIF GSGSERKSLV SSCISWLAPY WGATGSVSDL
YRDQVRLCCA IVAELLKQPD PYLYEFVPKI VSSYYSIIPD GVEETTYLSL LFSKSFPFQV
KSSKHSQKFD EALVELSAVL AGAATIPNPK RPRLKGLELS SFLTQAFEVH NSILNCEAYP
ESWFSVHVYN HRATVKSLEY LATILTNKFL PSPDDAETFD TRLWETFFMT LLKVVSSDAL
ALETYPEQKR RAIWKIAGDV REQGADLLHS SWESIGWETT DEEREHYGLS KLGGYQVQYV
PGLVAPIIEL CLSVHEGLRH VAVDILRTMI LSEWGLNQDL SIIETEVISS LDNLFKRKNM
SESVVQKLFI AELSDHFEDS ADYDEDLSSA VKALIATVDE LLDLFVASQG GSMAESLHTL
RLMKYMKDMG REDIFIRYVH ELAQVQAEAG NFTEAGLALQ FHADLYDWDP KRTLPELLNP
AFPEQTSFER KEALYFTIIQ HFEDGKAWAH ALVCYKELAQ QYEDIVVDFA KLSRAHASMA
KIYDLISKES KQFPRYFRVQ YKGLGFPTTL RDKQFIIECA PTERMVSFID RMQREHPAAQ
VVSSGEVHDY EGQYLHINPV SVHRDVDHPV YQRSKIPQSV RDHLLVSEPC HFSSTLRKHV
RDVDVKEQWV EKTVYTTAEP FPNILRRSEV VEVKEVALSP LHTALERTWR KTHELSMLQR
RAASGEDTGL NNLSEALQQL LDLDAATPNC VAAYRQFLSD AHEEEEGGLV TPKPADPMKN
ALAVALIDHA LGIKQALALY HRPAHLATQA ELTRRFEEAF GPEISSLRPA ETEQAPQWPR
RSTPESVKER QKPPASRALS PEQELIRSSR KNHSRKHSAK QSVSHRISVM NPFKRGNHVA
SNSVSTVQED PKPQSDSKVN GTTTEEHVNG EVDQDDAATI HSRTTTQSRD THHKRRSRLG
DVLHKHASSL SISASATEET QSQKKQRTRS ASRDTAGKSH DSVSQTTSQT NGTSADDRPS
VSSHKGGWST IPSITDYPRP VTRSSINSVR SPELMSPVSQ SSGMRDSVFK RFSLLKGVSR
KGSRLDFRTE TPVREE
//
