ID A2QCD0_ASPNC Unreviewed; 734 AA.
AC A2QCD0;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE RecName: Full=Origin recognition complex subunit 4 {ECO:0000256|ARBA:ARBA00019083};
GN ORFNames=An02g03140 {ECO:0000313|EMBL:CAK47594.1};
OS Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011 {ECO:0000313|EMBL:CAK47594.1, ECO:0000313|Proteomes:UP000006706};
RN [1] {ECO:0000313|EMBL:CAK47594.1, ECO:0000313|Proteomes:UP000006706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892
RC {ECO:0000313|Proteomes:UP000006706};
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA van Ooyen A.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ORC4 family.
CC {ECO:0000256|ARBA:ARBA00005334}.
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DR EMBL; AM270003; CAK47594.1; -; Genomic_DNA.
DR RefSeq; XP_001399450.1; XM_001399413.1.
DR AlphaFoldDB; A2QCD0; -.
DR EnsemblFungi; CAK47594; CAK47594; An02g03140.
DR GeneID; 4978800; -.
DR KEGG; ang:An02g03140; -.
DR VEuPathDB; FungiDB:An02g03140; -.
DR HOGENOM; CLU_007115_3_0_1; -.
DR OrthoDB; 230201at2759; -.
DR Proteomes; UP000006706; Chromosome 4R.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000808; C:origin recognition complex; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR016527; ORC4.
DR InterPro; IPR032705; ORC4_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12087; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR12087:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF14629; ORC4_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006706}.
FT DOMAIN 297..469
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..81
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 140..158
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 80361 MW; EDCACBD3F8B3DA22 CRC64;
MKDPRASKRR RVSDAQVVDE DGDTTMGEGA QDAPTSPVIE QTKAASPAAE EPETPATSRS
KRRRSSPGAA VIEKENDEVQ ATDTPTRGGV RSSGRQRRAP QRYGDEVVNT PSGRRNASTP
GANGSTTRSA RRAKYVSETE GDEEEEEAEV DDDDDEDEPS PQPKRRPART RSKKATVRFE
TDKDDASKKR DESQISPTPD DYQDGLEDLV SMQLQQDLAS NDLTSTEQTV PANGEPLPDY
AAKLQALVQE GLTEELRLLT GYVTQKLNGK RRVPLKGLET EYHKVNHLIE QTVAVGEGNS
MLLLGSRGSG KTAIVETIIS TLGKSYKNDF HVVRLNGFLH TDDRLALREM WRQLGRETNT
EDEAGKVSSY ADTMATLLAL LSHPEELYGP SNESGTATAA KSIVIVLDEF DLFVTHPRQT
LLYNLFDIAQ ARKAPIAVIG LTTKVDVTEM LEKRVKSRFS HRYVYVPLPR SLETFSDICF
AGLNLEDEEI SELLELADAK ERAVLHSDSW GRLLEGWRAY LQGLWIDEAF TSHLRRIYHQ
TKSVKEFFTS ALIGLSDLYH STHFLTTPEG TSSLEIPTAT TFTSHLLSCP DPAPLPFSAS
TTASASPSSL PLSLLLAATR LAALYEPGLE TTQLQSAAPL ALSFPAAYAE YVRLLTTAKT
SASVSGAAVT PGRVWGRDVA REAWEKLVSW GLISPVGGGS GTADGRMFRV EISFDEVVEM
AGTGGSLGRW WRDG
//
