ID   A2QSW8_ASPNC            Unreviewed;      1244 AA.
AC   A2QSW8;
DT   06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT   06-MAR-2007, sequence version 1.
DT   27-MAR-2024, entry version 84.
DE   SubName: Full=Contig An08c0340, genomic contig {ECO:0000313|EMBL:CAK40096.1};
GN   ORFNames=An08g12210 {ECO:0000313|EMBL:CAK40096.1};
OS   Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011 {ECO:0000313|EMBL:CAK40096.1, ECO:0000313|Proteomes:UP000006706};
RN   [1] {ECO:0000313|EMBL:CAK40096.1, ECO:0000313|Proteomes:UP000006706}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892
RC   {ECO:0000313|Proteomes:UP000006706};
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA   Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA   van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA   Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA   Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA   Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA   Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA   van Ooyen A.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AM270189; CAK40096.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2QSW8; -.
DR   EnsemblFungi; CAK40096; CAK40096; An08g12210.
DR   VEuPathDB; FungiDB:An08g12210; -.
DR   HOGENOM; CLU_000680_23_2_1; -.
DR   Proteomes; UP000006706; Chromosome 8R.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR   CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR   CDD; cd01650; RT_nLTR_like; 1.
DR   Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR002156; RNaseH_domain.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   PANTHER; PTHR33481; REVERSE TRANSCRIPTASE; 1.
DR   PANTHER; PTHR33481:SF1; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF14529; Exo_endo_phos_2; 1.
DR   Pfam; PF00075; RNase_H; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF56219; DNase I-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50879; RNASE_H_1; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000006706}.
FT   DOMAIN          497..753
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   DOMAIN          926..1073
FT                   /note="RNase H type-1"
FT                   /evidence="ECO:0000259|PROSITE:PS50879"
SQ   SEQUENCE   1244 AA;  140990 MW;  4058E58E863F99F1 CRC64;
     MLENNLRILQ LNMMKSKPCM EALINDNQTQ NLDILLVQEP STTIYRSHVN HSAWRLHRPT
     VTSDSVRFRS LIYVNRRLST SSYQQVHCDQ PDLTAIKIRT PGLQILVFSV YIEPIPMHNP
     GEASARRVLS AIRDTIHSTL QNTKKTTSLI LSGDFNRHHP AWGGNHVQSR FIEDASELIN
     FFNTYSLRSC LPRGTATFWS LSHPGRNSTI DQTLTDRPGM LLKCHLYHDN YGSDHRATYS
     EWSLRMPRNP DTKPRKAYER ADWEKIGWDI WGSMRPWETP DTIETLDATV EKLILATATA
     IDKDIPNLQP SPYAKRWFTP DLKTQQKAVN QTRRKWQESC ARAGRDDPYT KLLSEDMRQK
     RRTWTRAIEK AKTAHWKQFL DRAGEGRLWK AATYMRPRES WSSVPALKVD NRSVTGNQEK
     AEAFMDTFFP TMAPAQEETP IRIPAELPWQ PITELEVYRS LQAAKSSTAP GEDGLPMLIW
     KRLWGHLGNL ITRIFAASID LGYHPRKWRS ARLVVLRKPG KSDYSIPGAY RPISLLNTLG
     KLLEAVMARR LSYLAEHYGL LPDTQFGGRP GRTTEQALLV LTNAIDRAWY GQRVVTLVAF
     DLKGAFNGVN KTSLDIRLQA KGIPKVARRW IASFMSGRQA RIGFDDYCSD VIPLGNAGLA
     QVSPLSPILF AFFNSDLVDQ PVNFHGGASA FIDDYFRWRE EKGTMSRSYH TINSSVITPT
     TAKLLGVIFD HELRWKEHVQ QAVKRATKVN VAIGGLRQLR PEQMRQLYEA CVTPVVQYAS
     TVWHDPLRDK THLRQLRTVQ RTALIRILSA FRTVATSTLD VEAYMLPTHL RLRQRAQTTI
     TQLHTLPRKH PIREVLLRAR RRRDNVGSHA RFPLAEALKT MNLERLDDLE MIDPAPQPPW
     RAEAFSKIDI ATNREIAMEQ AEAARSESDL VVYSDASGRQ GHLGAAAAVL DDESVTTESL
     QIQVGPTDQW SVHAAELIGI LYAINLINRI VLQQRRAGQK RARTVTILSD STSALLAIQK
     PGSKSGQQII YAILQAAKNT RTHGVTIRLQ WVPGHSEILG NDAADRLAKE AAIPGKTHPF
     SPLLSRERAY IRQGILTQWE KEWKESRDGG HLRKIDNTLP AKYTRRLYGA LPRNRAYLLT
     QIRSGHCWLS TYGKLFGFRD DDRCLCGGRE SIIHVLLDCP LLRDLRRELR AKVGDALNSM
     SVLLGGSGSC QEGGSRVSNA SRTKTVEAVL DFAEASQRFR SRVP
//