ID A2R2Q0_ASPNC Unreviewed; 843 AA.
AC A2R2Q0;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Contig An14c0080, genomic contig {ECO:0000313|EMBL:CAK46466.1};
DE EC=3.4.21.- {ECO:0000313|EMBL:CAK46466.1};
GN ORFNames=An14g01530 {ECO:0000313|EMBL:CAK46466.1};
OS Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011 {ECO:0000313|EMBL:CAK46466.1, ECO:0000313|Proteomes:UP000006706};
RN [1] {ECO:0000313|EMBL:CAK46466.1, ECO:0000313|Proteomes:UP000006706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892
RC {ECO:0000313|Proteomes:UP000006706};
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA van Ooyen A.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM270315; CAK46466.1; -; Genomic_DNA.
DR AlphaFoldDB; A2R2Q0; -.
DR EnsemblFungi; CAK46466; CAK46466; An14g01530.
DR VEuPathDB; FungiDB:An14g01530; -.
DR HOGENOM; CLU_009240_0_0_1; -.
DR Proteomes; UP000006706; Chromosome 1R.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00306; Peptidases_S8_S53; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR PANTHER; PTHR43806:SF59; CEREVISIN-RELATED; 1.
DR PANTHER; PTHR43806; PEPTIDASE S8; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR PRINTS; PR00723; SUBTILISIN.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU01240};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000006706};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW ProRule:PRU01240}; Signal {ECO:0000256|ARBA:ARBA00022729};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 598..813
FT /note="Peptidase S8/S53"
FT /evidence="ECO:0000259|Pfam:PF00082"
FT REGION 135..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 605
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 643
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
FT ACT_SITE 798
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01240"
SQ SEQUENCE 843 AA; 95451 MW; 7FA330394413959E CRC64;
MASEDPIDFA YTAIAQVANI ASLLGVESKR PLCGRLGAEL FLVANYIDTA GLDQERRLRL
RISKLLRDVE AMCNWPKDIP RNGYPLLEAI GRSLPGVTSY EKARKSIRRG LDQLTSCPRD
AEVAISHVQK FIERNRKSTR RDESGDLSSR KRFARPERSD LANELAHRVL REQMCCTCQS
NGVRRQMERG HLVCLLLQPP SQSVASNNLA QFDMLFSSKP FWDQSQLTHW QDVELLVPND
HTPSKKCVRF LDEDVGNDDQ HASKTTAKRR HRTDKGQFCR LLDLATGWRL CLSIEDQELY
HRFGPHKQVV DHTPGISLAK ILSTYYLTAR MKLVLAYIIA YSVWQYYDTD WMRTRWTSET
IQFMRESNSS GDGGRGKLFT WKPYVSVHFN DEDPLCYEQY RIAGMVHVYP RIRALGIMLV
EIGLGFPLPK REEQGRPLAA EVNTELLTAI NYARDEEHWK NFDYPDYKSS ICHCLEPGTF
DQAPCVESLS ASEQKQNLKQ RRNILYEKVV FPLENLLQGT KWIDNYEKIG PLHVLSQDAA
IQEATVPVNS DKGKAPERRR KRTESEKNAS NWLLDVKEFN RELAQVAPAA GLHGLSRRVR
IAILDTGYDD NAPFFFSPDV MERLKGWKDW ADGSIQPEDC HGHGTHLVSL VLKCAPDADI
YVARIAKRPQ QLLSASEKVA EAISWASEQW EADLISMSFG FAEEQPCISD AIREALYKRK
DSILFFAAAS NYGANDREMF PARHESVMSI RATNSNGLFA DFNPPKHEDE PVVFGTLGID
VPSAWPNCDG EEYRSGTSIA TAIAAGIAGS LLGYISSHPP EKPFYDAKTR LFVPDGTGLD
RHS
//
