ID A2R925_ASPNC Unreviewed; 990 AA.
AC A2R925;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=116 kDa U5 small nuclear ribonucleoprotein component {ECO:0000256|ARBA:ARBA00018774};
DE AltName: Full=U5 snRNP-specific protein, 116 kDa {ECO:0000256|ARBA:ARBA00031432};
GN ORFNames=An16g09200 {ECO:0000313|EMBL:CAK47116.1};
OS Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=425011 {ECO:0000313|EMBL:CAK47116.1, ECO:0000313|Proteomes:UP000006706};
RN [1] {ECO:0000313|EMBL:CAK47116.1, ECO:0000313|Proteomes:UP000006706}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 513.88 / FGSC A1513 / ATCC MYA-4892
RC {ECO:0000313|Proteomes:UP000006706};
RX PubMed=17259976; DOI=10.1038/nbt1282;
RA Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA Bendtsen J.D., Benen J.A., van den Berg M., Breestraat S., Caddick M.X.,
RA Contreras R., Cornell M., Coutinho P.M., Danchin E.G., Debets A.J.,
RA Dekker P., van Dijck P.W., van Dijk A., Dijkhuizen L., Driessen A.J.,
RA d'Enfert C., Geysens S., Goosen C., Groot G.S., de Groot P.W.,
RA Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.,
RA van den Hondel C.A., van der Heijden R.T., van der Kaaij R.M., Klis F.M.,
RA Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA van der Maarel M.J., Meulenberg R., Menke H., Mortimer M.A., Nielsen J.,
RA Oliver S.G., Olsthoorn M., Pal K., van Peij N.N., Ram A.F., Rinas U.,
RA Roubos J.A., Sagt C.M., Schmoll M., Sun J., Ussery D., Varga J.,
RA Vervecken W., van de Vondervoort P.J., Wedler H., Wosten H.A., Zeng A.P.,
RA van Ooyen A.J., Visser J., Stam H.;
RT "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT niger CBS 513.88.";
RL Nat. Biotechnol. 25:221-231(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AM270382; CAK47116.1; -; Genomic_DNA.
DR AlphaFoldDB; A2R925; -.
DR EnsemblFungi; CAK47116; CAK47116; An16g09200.
DR HOGENOM; CLU_002794_11_2_1; -.
DR Proteomes; UP000006706; Chromosome 5R.
DR GO; GO:0071014; C:post-mRNA release spliceosomal complex; IEA:EnsemblFungi.
DR GO; GO:0000974; C:Prp19 complex; IEA:EnsemblFungi.
DR GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:EnsemblFungi.
DR GO; GO:0005682; C:U5 snRNP; IEA:EnsemblFungi.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:EnsemblFungi.
DR GO; GO:0030623; F:U5 snRNA binding; IEA:EnsemblFungi.
DR GO; GO:0000349; P:generation of catalytic spliceosome for first transesterification step; IEA:EnsemblFungi.
DR GO; GO:0000244; P:spliceosomal tri-snRNP complex assembly; IEA:EnsemblFungi.
DR GO; GO:0000388; P:spliceosome conformational change to release U4 (or U4atac) and U1 (or U11); IEA:EnsemblFungi.
DR CDD; cd04098; eEF2_C_snRNP; 1.
DR CDD; cd04090; EF2_II_snRNP; 1.
DR CDD; cd01683; EF2_IV_snRNP; 1.
DR CDD; cd16264; snRNP_III; 1.
DR CDD; cd04167; Snu114p; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 3.90.1430.10; Yeast translation eEF2 (G' domain); 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR031950; EFTUD2_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR044121; Snu114_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR InterPro; IPR035655; U5-116kDa_C.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42908:SF6; 116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF16004; EFTUD2; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006706};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 137..447
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 990 AA; 110145 MW; F17A643F67D5824E CRC64;
MDDLYDEFGN YIGEVDGSDD ESPHNEDAHP QAFAFEEAFG DGDVDEAHDV DEQQLMDVDG
RGPSNAVILH EDKQYYPSAQ QVYGQDVETL VQEEDAQPLS EPIIAPVQQK KFAIEEAELP
PVYYSREFMT DLLSYPDQIR NIALVGHLHH GKTAFMDMLV TQTHDLTGRL ENRTGKRKEE
QLRYTDIHFL ERERGLSIKA SPMSLVLQGT KGKSHLFNVI DTPGHVNFVD EVATACRLVD
GVVLVVDVVE GVQANTEQII KHAILEDLPL TLVVNKMDRL ILELKIPPND AYFKLKHVIE
EVNTIIENVL PGQGAARRLS PEKGNVAFAC ASMGWCFTLH SFAKMYAETH PQIEAAEFCL
RLWGDIFFNP RSRKFTRKGV EESSKRTFVQ FVLEPIYKLY SHTLSESPED LKETLSSVGI
SLKPSQLKTD AKTLLNLVCE QFFGSATGFV DMVLQHVPSP AEGAQKKLDR YYTGPLDSKV
ATAMAACDSD GPLVVHVTKL FNSSDGSRFH SFGRVMSGTA RPGQQVRVLG EGYTPEDEED
MVIATISDTW IAESCYNIPT SGVPSGNFVL LGGVDNSIVK TATIVPLTLE DDEDAYIFRS
IRHITESVFK VAVEPVNPSE LPKMLEGLRK VNKSYPLIST KVEESGEHVV LGTGELYMDC
VLHDLRRLYS EMEIKVSDPV TRFCETVVET SAIMCYSITP NKKNKITMIA EPLDEGIAED
IESGAVNIKD PIRKVSRFFE ERYDWDKLAA RSIWAFGPDE MGPNILQDDT LPSQIDKKLL
GSVRDSITQG FTWGTREGPL CEEPIRNAKF RLTDVSLADQ AIYRGGGQII PTARRAIYSS
FLMASPRLME PIYSCTMTGP ADAVASVYTV LSRRRGHVLS DGPIAGTPLY SVRGLIPVID
SFGFETDLRI HTQGQAAVSL VFDKWSVVPG DPLDRDVKLK PLEMAPAMAT ARDFVLKTRR
RKGLAEDVTV SKFLEPELWK GLKESGVLDS
//
