ID A2T0L4_TASV2 Unreviewed; 226 AA.
AC A2T0L4;
DT 06-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 06-MAR-2007, sequence version 1.
DT 08-NOV-2023, entry version 65.
DE RecName: Full=Non-structural polyprotein 1AB {ECO:0000256|ARBA:ARBA00019743};
DE Flags: Fragment;
OS Turkey astrovirus 2 (TAstV-2).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC Stellavirales; Astroviridae; Avastrovirus; Avastrovirus 3.
OX NCBI_TaxID=246343 {ECO:0000313|EMBL:ABF06846.1};
OH NCBI_TaxID=9103; Meleagris gallopavo (Wild turkey).
RN [1] {ECO:0000313|EMBL:ABF06846.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=82/1/04 {ECO:0000313|EMBL:ABF06846.1};
RX PubMed=17106624; DOI=10.1007/s00705-006-0862-4;
RA Cattoli G., De Battisti C., Toffan A., Salviato A., Lavazza A., Cerioli M.,
RA Capua I.;
RT "Co-circulation of distinct genetic lineages of astroviruses in turkeys and
RT guinea fowl.";
RL Arch. Virol. 152:595-602(2007).
CC -!- FUNCTION: Contains the viral protease participating in the cleavage of
CC the polyprotein into functional products. It contains also the
CC activities necessary for replication of genomic RNA, as well as
CC transcription of subgenomic mRNA. {ECO:0000256|ARBA:ARBA00029407}.
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000256|ARBA:ARBA00004301};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004301}.
CC -!- SIMILARITY: Belongs to the astroviridae polyprotein 1AB family.
CC {ECO:0000256|ARBA:ARBA00005873}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ381381; ABF06846.1; -; Genomic_RNA.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23172; ps-ssRNAv_Astroviridae_RdRp; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR Pfam; PF00680; RdRP_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953}.
FT DOMAIN 9..143
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABF06846.1"
FT NON_TER 226
FT /evidence="ECO:0000313|EMBL:ABF06846.1"
SQ SEQUENCE 226 AA; 26562 MW; D32C5C0C3B05AA21 CRC64;
RRLYGDGDRY FVEMDWTRYD GTIPKSLFWR IRQIRFFFLH DSHKTPKMQR LYNWYVKNLL
EKIILLPTGE VCQVKKGNPS GQYSTTVDNN MINVWLTTFE ISYLFFKQRG RLPTEKELQE
NCSMICYGDD RLLSIRKGFV EYEPETVIEM YKNIFGMWVK RSNIKIQDTP EGLSFCGLTI
VKSSTGAYVG VPNVNKILST LENPVRRLPD VESLWGKLVS LRILCE
//
