ID A2W8M1_9BURK Unreviewed; 950 AA.
AC A2W8M1; A0A0D5J4B6;
DT 20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 20-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=BDAG_01030 {ECO:0000313|EMBL:EAY68317.1};
OS Burkholderia dolosa AU0158.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=350701 {ECO:0000313|EMBL:EAY68317.1, ECO:0000313|Proteomes:UP000053482};
RN [1] {ECO:0000313|Proteomes:UP000053482}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AU0158 {ECO:0000313|Proteomes:UP000053482};
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L.,
RA Jaffe D., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M.,
RA Mauceli E., Brockman W., Rounsley S., Young S., LaButti K., Pushparaj V.,
RA DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P.,
RA Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., Oleary S.,
RA Alvarado L., Lory S., LiPuma J.;
RT "The Genome Sequence of Burkholderia dolosa (strain AU0158).";
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; CH482380; EAY68317.1; -; Genomic_DNA.
DR RefSeq; WP_006763804.1; NZ_CP009795.1.
DR AlphaFoldDB; A2W8M1; -.
DR GeneID; 64460598; -.
DR PATRIC; fig|350701.8.peg.914; -.
DR HOGENOM; CLU_000445_113_1_4; -.
DR OrthoDB; 9806130at2; -.
DR Proteomes; UP000053482; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd01987; USP_OKCHK; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.20.120.620; Backbone structure of the membrane domain of e. Coli histidine kinase receptor kdpd; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR038318; KdpD_sf.
DR InterPro; IPR025201; KdpD_TM.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR003852; Sig_transdc_His_kinase_KdpD_N.
DR PANTHER; PTHR45569; SENSOR PROTEIN KDPD; 1.
DR PANTHER; PTHR45569:SF1; SENSOR PROTEIN KDPD; 1.
DR Pfam; PF13493; DUF4118; 1.
DR Pfam; PF13492; GAF_3; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF02702; KdpD; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ion channel {ECO:0000313|EMBL:EAY68317.1};
KW Ion transport {ECO:0000313|EMBL:EAY68317.1};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EAY68317.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000313|EMBL:EAY68317.1};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
SQ SEQUENCE 950 AA; 103734 MW; 009D01398311E453 CRC64;
MNRPDPDRLL DKLQRDEEKQ RRGQLKIFFG ASAGVGKTYA MLQAARQRKQ DGIDVVVGIV
ETHGRSETAA LLDGLDVLPL ARLAHRGRML AEFDLDAALA RAPQLILVDE LAHSNVPGAR
HLKRWQDVYE LLDAGIDVYT TVNVQHLESL NDVVGAITGI RVWETVPDRV FDAADEVTLV
DLPAEELLER MRDGKVYLAQ QAERAVRNFF RKGNLIALRE LALRRTADRV DAQMREYRAD
RSIQRIWQAR ERLLVCVGPG AEAPTLVRAA ARLAASLKAD WIAVYVETPR LQRRADAQRQ
RTLDALKLAA ELGAQTATLT GNDAVAALIG YATVRNVSKI VAGGSRKVGL VRRFARPFGE
RLAERAGDVD LMLLRASASG DARAAPLDAA ARDWRDAFAP FGAHRSPPRH YAYAAAICAA
ITVVASAVSA RLDLTNLVML YLLGVVFSAV RLGRGPGVLQ SFLSVAAFDF FFVPPRMSFS
VSDTQYLLTF FGMLLTSLVI SHLTSTLTRE ASIAQRRERR TDAIYAMARE LGAALTIEQI
VEIGSRHVGE VFRARVAFLL PDSADQVRQK IDEPDAAVTL TGAELDSDVG QWVYDQQKPA
GRGTDTLPAA AALYLPLKAP MRTRGVLAVA SREPREFDVP EQRRMLDAFA AQIALALERV
HYVEIARDAL VSMESERLRN SLLSAISHDL RTPLTTIVGF SSMLANGRSA APSDDPAAAA
RSAQRESELV DAIHDEALRM TGIVTNLLDM ARLQAGSLQL KREWSLLEET VGAALAACRR
VLARHPVRVS LPADLPLLQM DAVLMERLFA NLFENAAKYT RPDTPIDIGA QRVTEDGKPF
VRVHVDDGGP GLPAGMEARI FDKFTRGEKE SATPGIGLGL AICRAIVDAH GGRIGAFNRT
APDGRVTGAR FWFTLPVDVP PAAPAVPDEP DVQPDALPAP SSSERSPDHE
//
