ID A3CPV7_STRSV Unreviewed; 258 AA.
AC A3CPV7;
DT 20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 20-MAR-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Aminoglycoside phosphotransferase, putative {ECO:0000313|EMBL:ABN45212.1};
DE EC=2.7.1.95 {ECO:0000313|EMBL:ABN45212.1};
GN OrderedLocusNames=SSA_1830 {ECO:0000313|EMBL:ABN45212.1};
OS Streptococcus sanguinis (strain SK36).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=388919 {ECO:0000313|EMBL:ABN45212.1, ECO:0000313|Proteomes:UP000002148};
RN [1] {ECO:0000313|EMBL:ABN45212.1, ECO:0000313|Proteomes:UP000002148}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK36 {ECO:0000313|EMBL:ABN45212.1,
RC ECO:0000313|Proteomes:UP000002148};
RX PubMed=17277061; DOI=10.1128/JB.01808-06;
RA Xu P., Alves J.M., Kitten T., Brown A., Chen Z., Ozaki L.S., Manque P.,
RA Ge X., Serrano M.G., Puiu D., Hendricks S., Wang Y., Chaplin M.D., Akan D.,
RA Paik S., Peterson D.L., Macrina F.L., Buck G.A.;
RT "Genome of the opportunistic pathogen Streptococcus sanguinis.";
RL J. Bacteriol. 189:3166-3175(2007).
CC -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC {ECO:0000256|ARBA:ARBA00006219, ECO:0000256|PIRNR:PIRNR000706}.
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DR EMBL; CP000387; ABN45212.1; -; Genomic_DNA.
DR RefSeq; WP_011837397.1; NC_009009.1.
DR RefSeq; YP_001035762.1; NC_009009.1.
DR AlphaFoldDB; A3CPV7; -.
DR STRING; 388919.SSA_1830; -.
DR KEGG; ssa:SSA_1830; -.
DR PATRIC; fig|388919.9.peg.1736; -.
DR eggNOG; COG3231; Bacteria.
DR HOGENOM; CLU_073027_1_0_9; -.
DR OrthoDB; 3806873at2; -.
DR Proteomes; UP000002148; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008910; F:kanamycin kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05150; APH; 1.
DR Gene3D; 3.90.1200.10; -; 1.
DR InterPro; IPR002575; Aminoglycoside_PTrfase.
DR InterPro; IPR024165; Kan/Strep_kinase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR Pfam; PF01636; APH; 1.
DR PIRSF; PIRSF000706; Kanamycin_kin; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|PIRNR:PIRNR000706};
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000706};
KW Kinase {ECO:0000256|PIRNR:PIRNR000706};
KW Magnesium {ECO:0000256|PIRSR:PIRSR000706-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR000706-2};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000706};
KW Reference proteome {ECO:0000313|Proteomes:UP000002148};
KW Transferase {ECO:0000256|PIRNR:PIRNR000706, ECO:0000313|EMBL:ABN45212.1}.
FT DOMAIN 37..249
FT /note="Aminoglycoside phosphotransferase"
FT /evidence="ECO:0000259|Pfam:PF01636"
FT ACT_SITE 182
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000706-1"
FT BINDING 187
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000706-2"
FT BINDING 201
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR000706-2"
SQ SEQUENCE 258 AA; 29581 MW; D78FED83D98B7921 CRC64;
MKAEKISLSL AQFPEQIRTY LEGANFYDSS SHSAASVFYT DTGYYLKIDQ KDQLAQEATL
AKWFEEQGLG VPVVHYLTAD KDYLLTKEAE GKDALAFLQQ PEELCQTMAA ALRKLHSLQP
QHFPIQHRLQ HYKEQAEENY QKGCFYQKAL LPQFHIQSRE EAYQLIQEQG HLLTADALIH
GDAFLSNFIL KDAATFSCFI DVGLAGLSNR HIDLYWAIWS LTYNLSDPQY AELFLDYYGR
KDVDTDKLRL IAAFEAFG
//
