ID A3F768_HUMAN Unreviewed; 690 AA.
AC A3F768;
DT 20-MAR-2007, integrated into UniProtKB/TrEMBL.
DT 20-MAR-2007, sequence version 1.
DT 22-FEB-2023, entry version 87.
DE SubName: Full=NF-kappaB repressing factor {ECO:0000313|EMBL:ABN11234.1};
GN Name=NRF {ECO:0000313|EMBL:ABN11234.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ABN11234.1};
RN [1] {ECO:0000313|EMBL:ABN11234.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=10562553; DOI=10.1093/emboj/18.22.6415;
RA Nourbakhsh M., Hauser H.;
RT "Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kB-
RT repressing factor), a nuclear inhibitor of NF-kB.";
RL EMBO J. 18:6415-6425(1999).
RN [2] {ECO:0000313|EMBL:ABN11234.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16107696; DOI=10.1128/MCB.25.17.7473-7483.2005;
RA Dreikhausen U., Hiebenthal-Millow K., Bartels M., Resch K., Nourbakhsh M.;
RT "NF-kappaB-repressing factor inhibits elongation of human immunodeficiency
RT virus type 1 transcription by DRB sensitivity-inducing factor.";
RL Mol. Cell. Biol. 25:7473-7483(2005).
RN [3] {ECO:0000313|EMBL:ABN11234.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17592041; DOI=10.1261/rna.545407;
RA Reboll M.R., Oumard A., Gazdag A.C., Renger I., Ritter B., Schwarzer M.,
RA Hauser H., Wood M., Yamada M., Resch K., Nourbakhsh M.;
RT "NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt
RT RNA element.";
RL RNA 13:1328-1340(2007).
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DR EMBL; EF216688; ABN11234.1; -; mRNA.
DR RefSeq; NP_001166959.1; NM_001173488.1.
DR AlphaFoldDB; A3F768; -.
DR IntAct; A3F768; 1.
DR PeptideAtlas; A3F768; -.
DR PharmGKB; PA134990602; -.
DR BioGRID-ORCS; 55922; 11 hits in 784 CRISPR screens.
DR ChiTaRS; NKRF; human.
DR GenomeRNAi; 55922; -.
DR Genevisible; A3F768; HS.
DR GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR CDD; cd02640; R3H_NRF; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR034071; R3H_NRF.
DR PANTHER; PTHR16148:SF15; NF-KAPPA-B-REPRESSING FACTOR; 1.
DR PANTHER; PTHR16148; NF-KAPPA-B-REPRESSING FACTOR-RELATED; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF01424; R3H; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS51061; R3H; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 551..596
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT DOMAIN 600..664
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT REGION 27..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 690 AA; 77574 MW; 30630F3FBBABDF8F CRC64;
MEKILQMAEG IDIGEMPSYD LVLSKPSKGQ KRHLSTCDGQ NPPKKQAGSK FHARPRFEPV
HFVASSSKDE GQEDPYGPQT KEVNEQTHFA SMPRDIYQDY TQDSFSIQDG NSQYCDSSGF
ILTKDQPVTA NMYFDSGNPA PSTTSQQANS QSTPEPSPSQ TFPESVVAEK QYFIEKLTAT
IWKNLSNPEM TSGSDKINYT YMLTRCIQAC KTNPEYIYAP LKEIPPADIP KNKKLLTDGY
ACEVRCQNIY LTTGYAGSKN GSRDRATELA VKLLQKRIEV RVVRRKFKHT FGEDLVVCQI
GMSSYEFPPA LKPPEDLVVL GKDASGQPIF NASAKHWTNF VITENANDAI GILNNSASFN
KMSIEYKYEM MPNRTWRCRV FLQDHCLAEG YGTKKTSKHA AADEALKILQ KTQPTYPSVK
SSQCHTGSSP RGSGKKKDIK DLVVYENSSN PVCTLNDTAQ FNRMTVEYVY ERMTGLRWKC
KVILESEVIA EAVGVKKTVK YEAAGEAVKT LKKTQPTVIN NLKKGAVEDV ISRNEIQGRS
AEEAYKQQIK EDNIGNQLLR KMGWTGGGLG KSGEGIREPI SVKEQHKREG LGLDVERVNK
IAKRDIEQII RNYARSESHT DLTFSRELTN DERKQIHQIA QKYGLKSKSH GVGHDRYLVV
GRKRRKEDLL DQLKQEGQVG HYELVMPQAN
//
