ID A3I3B6_9BACT Unreviewed; 621 AA.
AC A3I3B6;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 11-JAN-2011, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Divalent metal cation transporter MntH {ECO:0000256|HAMAP-Rule:MF_00221};
GN Name=mntH {ECO:0000256|HAMAP-Rule:MF_00221};
GN ORFNames=ALPR1_17473 {ECO:0000313|EMBL:EAZ79142.2};
OS Algoriphagus machipongonensis.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC Algoriphagus.
OX NCBI_TaxID=388413 {ECO:0000313|EMBL:EAZ79142.2, ECO:0000313|Proteomes:UP000003919};
RN [1] {ECO:0000313|EMBL:EAZ79142.2, ECO:0000313|Proteomes:UP000003919}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PR1 {ECO:0000313|EMBL:EAZ79142.2,
RC ECO:0000313|Proteomes:UP000003919};
RX PubMed=21183675; DOI=10.1128/JB.01421-10;
RA Alegado R.A., Ferriera S., Nusbaum C., Young S.K., Zeng Q., Imamovic A.,
RA Fairclough S.R., King N.;
RT "Complete genome sequence of Algoriphagus sp. PR1, bacterial prey of a
RT colony-forming choanoflagellate.";
RL J. Bacteriol. 193:1485-1486(2011).
CC -!- FUNCTION: H(+)-stimulated, divalent metal cation uptake system.
CC {ECO:0000256|HAMAP-Rule:MF_00221}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00221};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00221}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000256|HAMAP-
CC Rule:MF_00221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_00221}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAZ79142.2}.
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DR EMBL; AAXU02000001; EAZ79142.2; -; Genomic_DNA.
DR RefSeq; WP_008202438.1; NZ_CM001023.1.
DR AlphaFoldDB; A3I3B6; -.
DR STRING; 388413.ALPR1_17473; -.
DR eggNOG; COG0589; Bacteria.
DR eggNOG; COG1914; Bacteria.
DR HOGENOM; CLU_020088_2_0_10; -.
DR OrthoDB; 9787548at2; -.
DR Proteomes; UP000003919; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR CDD; cd00293; USP_Like; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR HAMAP; MF_00221; NRAMP; 1.
DR InterPro; IPR001046; NRAMP_fam.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR006016; UspA.
DR NCBIfam; TIGR01197; nramp; 1.
DR NCBIfam; NF037982; Nramp_1; 1.
DR PANTHER; PTHR11706:SF101; MANGANESE TRANSPORTER SMF1; 1.
DR PANTHER; PTHR11706; SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER; 1.
DR Pfam; PF01566; Nramp; 1.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR00447; NATRESASSCMP.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00221};
KW Ion transport {ECO:0000256|HAMAP-Rule:MF_00221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00221};
KW Reference proteome {ECO:0000313|Proteomes:UP000003919};
KW Symport {ECO:0000256|HAMAP-Rule:MF_00221};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_00221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_00221};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_00221}.
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 59..82
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 103..128
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 134..152
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 201..220
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 241..270
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 295..318
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 339..356
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 362..383
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 403..421
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT TRANSMEM 436..458
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00221"
FT DOMAIN 488..620
FT /note="UspA"
FT /evidence="ECO:0000259|Pfam:PF00582"
SQ SEQUENCE 621 AA; 67808 MW; 5AFB6C1A8A898CD3 CRC64;
MSSESLSEVH GSVPTHNKKG WRKILAFLGP AYLVSVGYMD PGNWATDLAG GSEFGYKLLW
VLLMSNLMAL LLQSLSARLG VVCKLDLAQA SKQAYPKWAN IPLYILAEIA IAACDLAEIV
GMAIGLNLLF DLPLIWGVAI TALDTLLLLF LLNKGMRTME LFIISLVSII GFSFVVEMFI
VGPVYGEVVK GMVPSSLSGN ALYIAIGIIG ATVMPHNLYL HSSLVQTRKI DPSTKSIKNA
LKFNFIDSAI ALNLAFLVNA AILILAAAAF HVNGFYDVAE IQDASKLLEN LFGKIAPTFF
AIALIAAGQS STITGTLAGQ IVMEGHLKLR IQPWVRRMIT RLIAIIPAII TILYFGEEAL
GRLLVLSQVV LSLQLGFAVI PLIHFNSDRK LMKEHTIKLW VKILAWVCAG IIVFLNIQLV
INELQGWLVT AGDNAIYLYT IVIPLILACF ALLVYIFIHP FIKPGELKKR LVPHAKGVDF
IEGQPISYQH IAIAVDFSDN TQAIIQNAIK LGGKSANYLF VHVVESAAAR YLGKNTLDHE
TQQDVNSLIQ YQDKLISLGY NASHELGFGV AATEIAKIVN DQKVDLVIMG AHGHSGIKDL
LFGTTVNKLR HKIDTPILIV Q
//
