ID A3IJF2_9CHRO Unreviewed; 236 AA.
AC A3IJF2;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 24-JAN-2024, entry version 71.
DE RecName: Full=glutamyl-tRNA reductase {ECO:0000256|ARBA:ARBA00012970};
DE EC=1.2.1.70 {ECO:0000256|ARBA:ARBA00012970};
GN ORFNames=CY0110_19102 {ECO:0000313|EMBL:EAZ93934.1};
OS Crocosphaera chwakensis CCY0110.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
OC Chroococcales; Aphanothecaceae; Crocosphaera; Crocosphaera chwakensis.
OX NCBI_TaxID=391612 {ECO:0000313|EMBL:EAZ93934.1, ECO:0000313|Proteomes:UP000003781};
RN [1] {ECO:0000313|EMBL:EAZ93934.1, ECO:0000313|Proteomes:UP000003781}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCY0110 {ECO:0000313|EMBL:EAZ93934.1,
RC ECO:0000313|Proteomes:UP000003781};
RA Stal L., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G.,
RA Rogers Y.-H., Friedman R., Frazier M., Venter J.C.;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-
CC glutamyl-tRNA(Glu) + NADPH; Xref=Rhea:RHEA:12344, Rhea:RHEA-
CC COMP:9663, Rhea:RHEA-COMP:9680, ChEBI:CHEBI:15378, ChEBI:CHEBI:57501,
CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78442,
CC ChEBI:CHEBI:78520; EC=1.2.1.70;
CC Evidence={ECO:0000256|ARBA:ARBA00001415};
CC -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.
CC {ECO:0000256|ARBA:ARBA00005059}.
CC -!- SIMILARITY: Belongs to the glutamyl-tRNA reductase family.
CC {ECO:0000256|ARBA:ARBA00005916}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAZ93934.1}.
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DR EMBL; AAXW01000002; EAZ93934.1; -; Genomic_DNA.
DR AlphaFoldDB; A3IJF2; -.
DR eggNOG; COG0373; Bacteria.
DR UniPathway; UPA00251; UER00316.
DR Proteomes; UP000003781; Unassembled WGS sequence.
DR GO; GO:0008883; F:glutamyl-tRNA reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR000343; 4pyrrol_synth_GluRdtase.
DR InterPro; IPR015896; 4pyrrol_synth_GluRdtase_dimer.
DR InterPro; IPR036453; GluRdtase_dimer_dom_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR NCBIfam; TIGR01035; hemA; 1.
DR PANTHER; PTHR43120; GLUTAMYL-TRNA REDUCTASE 1, CHLOROPLASTIC; 1.
DR PANTHER; PTHR43120:SF1; GLUTAMYL-TRNA REDUCTASE 1, CHLOROPLASTIC; 1.
DR Pfam; PF00745; GlutR_dimer; 1.
DR Pfam; PF01488; Shikimate_DH; 1.
DR SUPFAM; SSF69075; Glutamyl tRNA-reductase dimerization domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Chlorophyll biosynthesis {ECO:0000256|ARBA:ARBA00023171}.
FT DOMAIN 2..111
FT /note="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA
FT reductase"
FT /evidence="ECO:0000259|Pfam:PF01488"
FT DOMAIN 125..225
FT /note="Tetrapyrrole biosynthesis glutamyl-tRNA reductase
FT dimerisation"
FT /evidence="ECO:0000259|Pfam:PF00745"
SQ SEQUENCE 236 AA; 26864 MW; 09457E3F255D8996 CRC64;
MVKHLVAKGA TSITIVNRSQ RRAEELAKKF PQAELTLVSL DTMMEVVGNS HLVFTSTGAT
EPILHQDNLK EVVSVEQGLM LFDISVPRNV ATNVQDMEIV ETYNVDDLKA VVAQNHASRR
QMALEAEGLL EEEVEAFELW WRSLETVPTI SCLRTKVESI REQELEKALS RLGTEFAEKH
QEVIEALTRG IVNKILHEPM VQLRAQQDIE ARQRCLQSLQ MLFDLELEIE IEKQFS
//