ID A3KPH5_DANRE Unreviewed; 225 AA.
AC A3KPH5; A0A8M6Z412;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE RecName: Full=Pentraxin family member {ECO:0000256|RuleBase:RU362112};
GN Name=crp7 {ECO:0000313|Ensembl:ENSDARP00000101055,
GN ECO:0000313|RefSeq:XP_005162932.1, ECO:0000313|RefSeq:XP_017209282.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070822-13};
GN Synonyms=CRP {ECO:0000313|RefSeq:XP_005162932.1,
GN ECO:0000313|RefSeq:XP_017209282.1}, zgc:171660
GN {ECO:0000313|RefSeq:XP_005162932.1,
GN ECO:0000313|RefSeq:XP_017209282.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000101055};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000101055, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000101055};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000101055}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000101055};
RG Ensembl;
RL Submitted (MAY-2013) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005162932.1, ECO:0000313|RefSeq:XP_017209282.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005162932.1,
RC ECO:0000313|RefSeq:XP_017209282.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|RuleBase:RU362112};
CC Note=Binds 2 calcium ions per subunit. {ECO:0000256|RuleBase:RU362112};
CC -!- SUBUNIT: Homopentamer. Pentaxin (or pentraxin) have a discoid
CC arrangement of 5 non-covalently bound subunits.
CC {ECO:0000256|RuleBase:RU362112}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362112}.
CC -!- SIMILARITY: Belongs to the pentraxin family.
CC {ECO:0000256|RuleBase:RU362112}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
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DR EMBL; BX001030; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005162932.1; XM_005162875.4.
DR RefSeq; XP_017209282.1; XM_017353793.2.
DR STRING; 7955.ENSDARP00000101055; -.
DR PaxDb; 7955-ENSDARP00000101055; -.
DR Ensembl; ENSDART00000109975.3; ENSDARP00000101055.2; ENSDARG00000071456.4.
DR Ensembl; ENSDART00000189178.1; ENSDARP00000155369.1; ENSDARG00000071456.4.
DR GeneID; 100124600; -.
DR AGR; ZFIN:ZDB-GENE-070822-13; -.
DR CTD; 100124600; -.
DR ZFIN; ZDB-GENE-070822-13; crp7.
DR eggNOG; ENOG502QT7Q; Eukaryota.
DR HOGENOM; CLU_032051_2_0_1; -.
DR OMA; NINYVEM; -.
DR OrthoDB; 4219275at2759; -.
DR TreeFam; TF330208; -.
DR Proteomes; UP000000437; Chromosome 24.
DR Bgee; ENSDARG00000071456; Expressed in intestine and 16 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0015485; F:cholesterol binding; IDA:ZFIN.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008142; F:oxysterol binding; IDA:ZFIN.
DR GO; GO:0051607; P:defense response to virus; IDA:ZFIN.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR030476; Pentaxin_CS.
DR InterPro; IPR001759; Pentraxin-related.
DR PANTHER; PTHR45869; C-REACTIVE PROTEIN-RELATED; 1.
DR PANTHER; PTHR45869:SF2; PENTAXIN; 1.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00895; PENTAXIN.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS00289; PTX_1; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU362112};
KW Metal-binding {ECO:0000256|RuleBase:RU362112};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU362112}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|RuleBase:RU362112"
FT CHAIN 17..225
FT /note="Pentraxin family member"
FT /evidence="ECO:0000256|RuleBase:RU362112"
FT /id="PRO_5006990830"
SQ SEQUENCE 225 AA; 24918 MW; 3BAAA8F76FB44E2E CRC64;
MLGFIFTLLI LTPAAAEVGL GGKVLLFPTQ SATSYVKLTP DKLLSLSAFT LCMRVATELQ
GGREVILFAY RTSEVDELNV WRENDGRLSM YIQSSSDAAR FYLPPLSTFQ THLCVSWESA
TGLTAFWVDG RRSLYQIYKK DASVRPGGTV LLGQDPDSYV GSFDANQCFI GEITDVKLWD
YVLSEIQIKA LYSNQDPLVP AGNVFDWDTV KYDVVGNVTV ANDNL
//