ID A3KPN4_DANRE Unreviewed; 447 AA.
AC A3KPN4; A0A8M2B5R1;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 03-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE SubName: Full=Pentraxin 3, long a {ECO:0000313|Ensembl:ENSDARP00000089444};
DE SubName: Full=Pentraxin-related protein PTX3 {ECO:0000313|RefSeq:XP_005159288.1};
GN Name=ptx3a {ECO:0000313|Ensembl:ENSDARP00000089444,
GN ECO:0000313|RefSeq:XP_005159288.1,
GN ECO:0000313|ZFIN:ZDB-GENE-030131-8720};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000089444};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000089444, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000089444};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000089444}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000089444};
RG Ensembl;
RL Submitted (AUG-2013) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005159288.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005159288.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01172}.
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DR EMBL; BX255887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005159288.1; XM_005159231.4.
DR STRING; 7955.ENSDARP00000089444; -.
DR PaxDb; 7955-ENSDARP00000089444; -.
DR Ensembl; ENSDART00000098673; ENSDARP00000089444; ENSDARG00000068275.
DR Ensembl; ENSDART00000098673.5; ENSDARP00000089444.4; ENSDARG00000068275.5.
DR GeneID; 101887125; -.
DR KEGG; dre:101887125; -.
DR AGR; ZFIN:ZDB-GENE-030131-8720; -.
DR CTD; 101887125; -.
DR ZFIN; ZDB-GENE-030131-8720; ptx3a.
DR eggNOG; ENOG502QUBX; Eukaryota.
DR HOGENOM; CLU_725544_0_0_1; -.
DR OMA; PAGCDMA; -.
DR OrthoDB; 4219275at2759; -.
DR PhylomeDB; A3KPN4; -.
DR TreeFam; TF330208; -.
DR Proteomes; UP000000437; Chromosome 18.
DR Bgee; ENSDARG00000068275; Expressed in hypochord and 26 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0001849; F:complement component C1q complex binding; IBA:GO_Central.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR030476; Pentaxin_CS.
DR InterPro; IPR001759; Pentraxin-related.
DR InterPro; IPR042837; PTX3.
DR PANTHER; PTHR46943; PENTRAXIN-RELATED PROTEIN PTX3; 1.
DR PANTHER; PTHR46943:SF1; PENTRAXIN-RELATED PROTEIN PTX3; 1.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00895; PENTAXIN.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS00289; PTX_1; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:A3KPN4};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..447
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041116209"
SQ SEQUENCE 447 AA; 49273 MW; 1F921F08902C82C4 CRC64;
MASKSMRTFL QTMCLVASLS MAVSDNYDDD IEVGFGHNYF NEIPDEDQLE DETPTPSPEP
CKNTAFTKWD KLFTMLENSQ MKENMLLQYA DDIIKVELQN LRGEMIQFVA QYGGSCASAV
ESSVRRAGTQ TESRLQNALD RAREVSADRY EQHDAVLQQL LAVSVNQAAQ LDRLEKGCLK
SGAFKNIQTR HLMQDVTETE NGGKLEKSLE TISSELQSIR EQLSLYTRSA FADKLPSGCD
TGLLFPTRSS KAHAEVSPHG LLRTNAVTIC LWVKPTQVFN KTLLFSYSTT GNAYELQLVL
SGQSASFTVD GESHLVEASG AVQEGQWGHL CASWSSQQGL ASLWVNGQQA ASSPGVAEGH
ELRSKGSILL GQEYGRHYKH LSTPDTFDAE LAFTGKMTGV NMWDRVLDPK EVSQQARLYG
TACGIRGNVV AWGVSDIQPK EGVKLLY
//
