ID A3LSY9_PICST Unreviewed; 617 AA.
AC A3LSY9;
DT 03-APR-2007, integrated into UniProtKB/TrEMBL.
DT 24-JUL-2007, sequence version 2.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN ORFNames=PICST_59048 {ECO:0000313|EMBL:ABN65977.2};
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104 {ECO:0000313|EMBL:ABN65977.2, ECO:0000313|Proteomes:UP000002258};
RN [1] {ECO:0000313|EMBL:ABN65977.2, ECO:0000313|Proteomes:UP000002258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545
RC {ECO:0000313|Proteomes:UP000002258};
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
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DR EMBL; CP000498; ABN65977.2; -; Genomic_DNA.
DR RefSeq; XP_001384006.2; XM_001383969.1.
DR AlphaFoldDB; A3LSY9; -.
DR STRING; 322104.A3LSY9; -.
DR GeneID; 4838644; -.
DR KEGG; pic:PICST_59048; -.
DR eggNOG; KOG2214; Eukaryota.
DR HOGENOM; CLU_009031_5_0_1; -.
DR InParanoid; A3LSY9; -.
DR OMA; SIVPWPH; -.
DR OrthoDB; 154387at2759; -.
DR Proteomes; UP000002258; Chromosome 4.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR CDD; cd07229; Pat_TGL3_like; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR PANTHER; PTHR14226:SF44; TRIACYLGLYCEROL LIPASE 3; 1.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000002258}.
FT DOMAIN 201..379
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
SQ SEQUENCE 617 AA; 71471 MW; 438C619627AB904F CRC64;
MFRSLAQVYV LPVVSFVINH TPSFIWVILD FFMDICFFWV KRLYSFYNSK DPLKEYLKHL
KNVKSYNEWK QTVAEIDKLT NMDLWRQNFI SKHYDYLLIN DRIKLLQQAR LSEDSSLIMS
LLRSGLIRNF GGISQKRLYI KSYMGTKFKI EEYIAEVLNC LNYLNESINS ERDNEEYIMN
SKQLKLDFFH DVRQSFGSTA LLLQGGSLFG LCHLGVVKAL YFKGLLPRII GGSAVGAAVA
SLVCTLTDQE LIPILISIAD VMKSMDRLNH DVDERYGNVI ENVVKKGYSE DILIFLKFVK
DTIGDLTFEE AYLKTEKVLN IVVHPTHQLV PSLLNYITAP NVIIWTAIYA SIGTGVLSDN
VQIYVKDFNN NIVPRSPDLN ITFLKPQDVT YSQQYFNFKK RDDNGGSFMF DNGQLKENSP
YTRLTELFNV NHFVISLARP YLAPLISNDL KHYHVYGKVR YNDTGHCKTK LLDIPATNTD
VELSKTYVDD VEKYTKDTTF TLFKHVKDIV GMEIQHRLVV MNKLGLLNDV MKRFFIDEKP
TSLQSLASIR EVTIVPELMY LVKDFGRVFD VHKTMENIPY WVLVGERSVW PLFPLLWTRC
SIEFALDDLY NIHRKKG
//
