ID   A4AFG3_9ACTN            Unreviewed;       413 AA.
AC   A4AFG3;
DT   03-APR-2007, integrated into UniProtKB/TrEMBL.
DT   03-APR-2007, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   SubName: Full=Type IV pilus biogenesis protein PilC {ECO:0000313|EMBL:EAR25719.1};
GN   ORFNames=A20C1_07563 {ECO:0000313|EMBL:EAR25719.1};
OS   marine actinobacterium PHSC20C1.
OC   Bacteria; Actinomycetota; Actinomycetes.
OX   NCBI_TaxID=312284 {ECO:0000313|EMBL:EAR25719.1, ECO:0000313|Proteomes:UP000003868};
RN   [1] {ECO:0000313|EMBL:EAR25719.1, ECO:0000313|Proteomes:UP000003868}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PHSC20C1 {ECO:0000313|EMBL:EAR25719.1,
RC   ECO:0000313|Proteomes:UP000003868};
RA   Murray A., Ferriera S., Johnson J., Kravitz S., Halpern A., Remington K.,
RA   Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the GSP F family.
CC       {ECO:0000256|ARBA:ARBA00005745}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EAR25719.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAOB01000002; EAR25719.1; -; Genomic_DNA.
DR   AlphaFoldDB; A4AFG3; -.
DR   STRING; 312284.A20C1_07563; -.
DR   eggNOG; COG1459; Bacteria.
DR   HOGENOM; CLU_035032_2_1_11; -.
DR   OrthoDB; 9805682at2; -.
DR   Proteomes; UP000003868; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.81.30; Type II secretion system (T2SS), domain F; 2.
DR   InterPro; IPR003004; GspF/PilC.
DR   InterPro; IPR018076; T2SS_GspF_dom.
DR   InterPro; IPR042094; T2SS_GspF_sf.
DR   PANTHER; PTHR30012; GENERAL SECRETION PATHWAY PROTEIN; 1.
DR   PANTHER; PTHR30012:SF0; TYPE II SECRETION SYSTEM PROTEIN F-RELATED; 1.
DR   Pfam; PF00482; T2SSF; 2.
DR   PRINTS; PR00812; BCTERIALGSPF.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003868};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        179..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        221..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        385..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          80..202
FT                   /note="Type II secretion system protein GspF"
FT                   /evidence="ECO:0000259|Pfam:PF00482"
FT   DOMAIN          282..404
FT                   /note="Type II secretion system protein GspF"
FT                   /evidence="ECO:0000259|Pfam:PF00482"
SQ   SEQUENCE   413 AA;  44743 MW;  53FC3E23EA95EB71 CRC64;
     MAATASTTKS FEYKARDQTG KVVKGRIDAP NENAVLARLR SMEISPISVI EAGTGTGLNM
     DINIAFLQKG VGLDDLAVMS RQMSTMISSG LSLIRALVIL SEQTENKTLA KALGEIRQDV
     ETGGTLSDAF AKHGTVFPPI MIHLVRAGET GGFLDDALES IANNFEGEVK LRGTIKSALT
     YPVVVLIMAI AAVVGMLIFI VPVFEEMFAD LGGELPLLTQ VLVWMSTGMK FAAPILIVAG
     IIFATWWRKN KHTERVRKFV DPWKLRMPVF GPLFRKVSIS RFTRNFGTML GAGVPILHAL
     SIVGETSGNY VIEEALRRVA DSVRSGQSVS APLARESVFP SMVTQMVAVG EDAGSMEVML
     SKIADFYDDE VQKTTEQLTA LIEPLMIGVI GAIVGVMVIA LYLPIFAIFD QIK
//