ID A4F6C9_SACEN Unreviewed; 606 AA.
AC A4F6C9;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Acyl-peptide hydrolase {ECO:0000256|ARBA:ARBA00032596};
DE AltName: Full=Acylaminoacyl-peptidase {ECO:0000256|ARBA:ARBA00032284};
GN OrderedLocusNames=SACE_0253 {ECO:0000313|EMBL:CAL99603.1};
GN ORFNames=A8924_0649 {ECO:0000313|EMBL:PFG93408.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAL99603.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAL99603.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAL99603.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG93408.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG93408.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AM420293; CAL99603.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG93408.1; -; Genomic_DNA.
DR RefSeq; WP_009947002.1; NZ_PDBV01000001.1.
DR AlphaFoldDB; A4F6C9; -.
DR STRING; 405948.SACE_0253; -.
DR MEROPS; S09.A77; -.
DR KEGG; sen:SACE_0253; -.
DR eggNOG; COG0823; Bacteria.
DR eggNOG; COG1506; Bacteria.
DR HOGENOM; CLU_008615_3_2_11; -.
DR OrthoDB; 128799at2; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008242; F:omega peptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002470; Peptidase_S9A.
DR PANTHER; PTHR42776:SF27; DIPEPTIDYL PEPTIDASE FAMILY MEMBER 6; 1.
DR PANTHER; PTHR42776; SERINE PEPTIDASE S9 FAMILY MEMBER; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR PRINTS; PR00862; PROLIGOPTASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Aminopeptidase {ECO:0000313|EMBL:PFG93408.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000313|EMBL:PFG93408.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT DOMAIN 399..604
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 606 AA; 65188 MW; 5848689D03A0B57C CRC64;
MRLDIVRLLG CTSRRAFDVD DSGRVLAGSD ESGSVQLAEI AGGEVSALTA LPGAVSGRYL
PGERAVVVQH DTDGDERSQL SLLTLDVPRT GPATMRDLRP LVHDSRYVHR LLDVLPGRVV
YATNRRNGVD FDVVVRSATS GAEEVVYDRG GMVLEAASSP DGRYLAVTVP AEKPLSDQII
LVDTMPVTAD EEVTELTDAD AHARHTGVRW LPDASALVVT TNLDRDRTGV ARIDPRTGER
RWLVTSDEHD LTGWLAPDGS TLLVQANVEG AARLALHDAA TGAVRRDVRL PGDGWCTYPL
PAPVWSPNSR FAALSYSSTA TPGDALLLDS GGEVRALTDS AAQLGSARPV PPTAHRVPTP
DGEQVPCFVY APENPPPDVA GSSVLFVHGG PEAQSVQAFN PIVQALVDQG HTVLVPNVRG
STGYGKRWYS ADDVRRRLSA VDDLAALHDW LPSLGLDPSR AALWGGSYGG YMVLAGLAFQ
PERWAAGVDI VGISSLLTFL ENTAAYRRAH REREYGSLRD DADFLREASP LTRADAISAP
LFVLHGANDP RVPLSEAEQL AQAVRAKGIE CELLVYADEG HGLAKRVNRL DAYPRALAFL
LRHLRR
//
