ID   A4FA08_SACEN            Unreviewed;       688 AA.
AC   A4FA08;
DT   17-APR-2007, integrated into UniProtKB/TrEMBL.
DT   17-APR-2007, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   SubName: Full=RNA polymerase primary sigma factor {ECO:0000313|EMBL:PFG94668.1};
GN   OrderedLocusNames=SACE_1561 {ECO:0000313|EMBL:CAM00883.1};
GN   ORFNames=A8924_1961 {ECO:0000313|EMBL:PFG94668.1};
OS   Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS   NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC   Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC   Pseudonocardiaceae; Saccharopolyspora.
OX   NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM00883.1, ECO:0000313|Proteomes:UP000006728};
RN   [1] {ECO:0000313|EMBL:CAM00883.1, ECO:0000313|Proteomes:UP000006728}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC   NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC   {ECO:0000313|EMBL:CAM00883.1};
RX   PubMed=17369815; DOI=10.1038/nbt1297;
RA   Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA   Haydock S.F., Leadlay P.F.;
RT   "Complete genome sequence of the erythromycin-producing bacterium
RT   Saccharopolyspora erythraea NRRL23338.";
RL   Nat. Biotechnol. 25:447-453(2007).
RN   [2] {ECO:0000313|EMBL:PFG94668.1, ECO:0000313|Proteomes:UP000225825}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG94668.1,
RC   ECO:0000313|Proteomes:UP000225825};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AM420293; CAM00883.1; -; Genomic_DNA.
DR   EMBL; PDBV01000001; PFG94668.1; -; Genomic_DNA.
DR   RefSeq; WP_009948174.1; NZ_PDBV01000001.1.
DR   AlphaFoldDB; A4FA08; -.
DR   STRING; 405948.SACE_1561; -.
DR   KEGG; sen:SACE_1561; -.
DR   eggNOG; ENOG502Z86Z; Bacteria.
DR   HOGENOM; CLU_389750_0_0_11; -.
DR   OrthoDB; 4273543at2; -.
DR   Proteomes; UP000006728; Chromosome.
DR   Proteomes; UP000225825; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   Pfam; PF01381; HTH_3; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006728}.
FT   DOMAIN          11..64
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50943"
SQ   SEQUENCE   688 AA;  74697 MW;  B425C137FBAB1A80 CRC64;
     MCSTKDFGST LEARMRIRGL SRKQFADLVG VTAAAVSSWT TGRVTPGTET MRRIEEVLGS
     SNESDGADGG TLTAGPGTLA WYHRPAHRDG GRELGNAAAF AFDTDLAVLA REATQNSLDE
     RFDGSEPVRV RYALHEITDE RLRSFLEALR WDEIEPHVEA AASPSNKVGR ILERGLADLR
     ENDRLVLLRI DDHNACGLTG PDYDDGRFSA VIRRQLDSRK ESPNAGGSYG LGKAVLWATS
     KLGLVLVNSH LSEPHEGLRG NRMIGRLELP WRRAEGGEWA GPAWFGEPDP ERGGATRSWW
     GDTATARRLH LERTDESPGT SFLIVGAHDP SGEADALEEM HDALVKALAN NFWASMVART
     SQAPMLEASV VAERDGEVVV PEQRVDPYLF EPTMTRALQA FLDGRTTSEL TAKHDVARVD
     VPLAVPRRKD EDSGSAHSHA AVLLVALADV VGGTPNRLVG MRGNRMVVVE GKIPDMPLGA
     PPVQAVLLAG RAAGGEGADA AEGFLRAAEP PEHNDWKRTD DLTSTYARGA ATRITEFRRA
     WKEAVHRLIR PTEEAKDDVP PALAGLLDLD APPARRSPGY PTVNDIDGAV QRDGSWRIQV
     DVQLPVREDS WVLEPILRFA TRSGPKPVVK WLLEPTLNCE LAESGALVFS KGARHAGFVG
     TSDPSSHPVT ADMAVVEVEL RRTSEVSP
//