ID A4FMC1_SACEN Unreviewed; 444 AA.
AC A4FMC1;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=4-aminobutyrate aminotransferase, PLP-dependent {ECO:0000313|EMBL:CAM05196.1};
DE EC=2.6.1.19 {ECO:0000313|EMBL:CAM05196.1};
DE SubName: Full=4-aminobutyrate aminotransferase/(S)-3-amino-2-methylpropionate transaminase {ECO:0000313|EMBL:PFG98843.1};
GN Name=gabT {ECO:0000313|EMBL:CAM05196.1};
GN OrderedLocusNames=SACE_6022 {ECO:0000313|EMBL:CAM05196.1};
GN ORFNames=A8924_6369 {ECO:0000313|EMBL:PFG98843.1};
OS Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 /
OS NBRC 13426 / NCIMB 8594 / NRRL 2338).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharopolyspora.
OX NCBI_TaxID=405948 {ECO:0000313|EMBL:CAM05196.1, ECO:0000313|Proteomes:UP000006728};
RN [1] {ECO:0000313|EMBL:CAM05196.1, ECO:0000313|Proteomes:UP000006728}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 /
RC NRRL 2338 {ECO:0000313|Proteomes:UP000006728}, and NRRL 2338
RC {ECO:0000313|EMBL:CAM05196.1};
RX PubMed=17369815; DOI=10.1038/nbt1297;
RA Oliynyk M., Samborskyy M., Lester J.B., Mironenko T., Scott N., Dickens S.,
RA Haydock S.F., Leadlay P.F.;
RT "Complete genome sequence of the erythromycin-producing bacterium
RT Saccharopolyspora erythraea NRRL23338.";
RL Nat. Biotechnol. 25:447-453(2007).
RN [2] {ECO:0000313|EMBL:PFG98843.1, ECO:0000313|Proteomes:UP000225825}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40517 {ECO:0000313|EMBL:PFG98843.1,
RC ECO:0000313|Proteomes:UP000225825};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC aminotransferase family. {ECO:0000256|ARBA:ARBA00008954,
CC ECO:0000256|RuleBase:RU003560}.
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DR EMBL; AM420293; CAM05196.1; -; Genomic_DNA.
DR EMBL; PDBV01000001; PFG98843.1; -; Genomic_DNA.
DR AlphaFoldDB; A4FMC1; -.
DR STRING; 405948.SACE_6022; -.
DR KEGG; sen:SACE_6022; -.
DR eggNOG; COG0160; Bacteria.
DR HOGENOM; CLU_016922_10_0_11; -.
DR Proteomes; UP000006728; Chromosome.
DR Proteomes; UP000225825; Unassembled WGS sequence.
DR GO; GO:0034386; F:4-aminobutyrate:2-oxoglutarate transaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009448; P:gamma-aminobutyric acid metabolic process; IEA:InterPro.
DR CDD; cd00610; OAT_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR004632; 4NH2But_aminotransferase_bac.
DR InterPro; IPR005814; Aminotrans_3.
DR InterPro; IPR049704; Aminotrans_3_PPA_site.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR00700; GABAtrnsam; 1.
DR PANTHER; PTHR11986; AMINOTRANSFERASE CLASS III; 1.
DR PANTHER; PTHR11986:SF58; LEUCINE_METHIONINE RACEMASE; 1.
DR Pfam; PF00202; Aminotran_3; 1.
DR PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 2.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:CAM05196.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|RuleBase:RU003560};
KW Reference proteome {ECO:0000313|Proteomes:UP000006728};
KW Transferase {ECO:0000313|EMBL:CAM05196.1}.
SQ SEQUENCE 444 AA; 47261 MW; BB6DA9235D328D02 CRC64;
MTTTMSLPQV RELRTEIPGP LSRELQQRRT AAVAAGVSSV LPVFVTEAAG GVLRDVDGNS
LIDLGSGIAV TNVGNAAPEV VEPVRRQAGE FTHTCFMVTP YENYLQVCEE LAQLTPGDHD
KRSALFNSGA EAVENAVKIA RRATGRQAVV VFDHAYHGRT NLTMALTAKS KPYKHGFGPF
APEVYRVPMS YPARDQRSGA ESAREAVDRI EKQLGADTVA AVMIEPLQGE GGFIEPAPGF
LPAISKWCTD NGVLFVADEI QTGFCRTGAW FACDHENVVP DLITTAKGIA GGLPLAAVTG
RAELMDALPP GSLGGTYGGN PLACAAALGS IRAMREQDLA AAARGIQDAV MPRLRSVAEY
TDRILDVRGR GAMIGVEFVK AGGDEPDPEL TSRIAKTCHE KGVVVLTCGT YGNVIRLLPP
LVIGHDLLDE GLRVLEEAIV EHTR
//
