ID A4G8J6_HERAR Unreviewed; 407 AA.
AC A4G8J6;
DT 17-APR-2007, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Acriflavine resistance protein A {ECO:0000313|EMBL:CAL62833.1};
GN Name=acrA2 {ECO:0000313|EMBL:CAL62833.1};
GN OrderedLocusNames=HEAR2713 {ECO:0000313|EMBL:CAL62833.1};
OS Herminiimonas arsenicoxydans.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Oxalobacteraceae; Herminiimonas.
OX NCBI_TaxID=204773 {ECO:0000313|EMBL:CAL62833.1, ECO:0000313|Proteomes:UP000006697};
RN [1] {ECO:0000313|EMBL:CAL62833.1, ECO:0000313|Proteomes:UP000006697}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ULPAs1 {ECO:0000313|Proteomes:UP000006697};
RX PubMed=17432936; DOI=10.1371/journal.pgen.0030053;
RA Muller D., Medigue C., Koechler S., Barbe V., Barakat M., Talla E.,
RA Bonnefoy V., Krin E., Arsene-Ploetze F., Carapito C., Chandler M.,
RA Cournoyer B., Cruveiller S., Dossat C., Duval S., Heymann M., Leize E.,
RA Lieutaud A., Lievremont D., Makita Y., Mangenot S., Nitschke W., Ortet P.,
RA Perdrial N., Schoepp B., Siguier N., Simeonova D.D., Rouy Z., Segurens B.,
RA Turlin E., Vallenet D., Van Dorsselaer A., Weiss S., Weissenbach J.,
RA Lett M.C., Danchin A., Bertin P.N.;
RT "A tale of two oxidation states: bacterial colonization of arsenic-rich
RT environments.";
RL PLoS Genet. 3:518-530(2007).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CU207211; CAL62833.1; -; Genomic_DNA.
DR AlphaFoldDB; A4G8J6; -.
DR STRING; 204773.HEAR2713; -.
DR KEGG; har:HEAR2713; -.
DR eggNOG; COG0845; Bacteria.
DR HOGENOM; CLU_018816_2_1_4; -.
DR OrthoDB; 9783047at2; -.
DR Proteomes; UP000006697; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000006697};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..407
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002669222"
FT DOMAIN 35..359
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 59..292
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 372..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 103..168
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 407 AA; 42515 MW; 1DA362B3A7D27C5C CRC64;
MSSLPRLTSL GAAFFILFAV AGCGKSDAPA AAPPPTEVSV VTIKSSALGV TNELPGRLES
TRIAEIRARV PGVVLKRTFR EGSDVKAGAT LFLIDPAQFK ATYNSANAAV ARAEATLLQA
ELKEKRYKPL VATNAISKQE YDDVTATLKQ AEADLAASKA ARETARLSLD YATVTSPISG
RIGRALVTEG ALVGQNEATP LATVQQIDPI YVNMTQSSTE ILQLQRALAD GKLKSAGKGQ
VKVTLVTEDG QEYAQPGKLL FSDLTVDASS GAITLRAEFP NPDSQLLPGM YVRARVEQAI
NENAITVPQQ AISRTPDGAA VMVVSAENTV VSRPVTTGAA SGDSWVISDG LKDGDQVIVE
GLQKIKPGAT VKPVQWKKTA PADATAPAAN PATSAPAAKT AEQPKSK
//
