ID   A4H3I8_LEIBR            Unreviewed;       724 AA.
AC   A4H3I8;
DT   01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2007, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   SubName: Full=Putative ABC transporter protein {ECO:0000313|EMBL:CAM36753.1};
GN   ORFNames=LBRM_03_0170 {ECO:0000313|EMBL:CAM36753.1};
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM36753.1, ECO:0000313|Proteomes:UP000007258};
RN   [1] {ECO:0000313|EMBL:CAM36753.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM36753.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
RN   [2] {ECO:0000313|EMBL:CAM36753.1, ECO:0000313|Proteomes:UP000007258}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM36753.1,
RC   ECO:0000313|Proteomes:UP000007258};
RX   PubMed=22038252; DOI=10.1101/gr.122945.111;
RA   Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA   Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA   Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA   Hertz-Fowler C., Mottram J.C.;
RT   "Chromosome and gene copy number variation allow major structural change
RT   between species and strains of Leishmania.";
RL   Genome Res. 21:2129-2142(2011).
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DR   EMBL; FR798977; CAM36753.1; -; Genomic_DNA.
DR   RefSeq; XP_001561607.1; XM_001561557.2.
DR   AlphaFoldDB; A4H3I8; -.
DR   STRING; 5660.A4H3I8; -.
DR   GeneID; 5412552; -.
DR   KEGG; lbz:LBRM_03_0170; -.
DR   VEuPathDB; TriTrypDB:LbrM.03.0170; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_030006600; -.
DR   InParanoid; A4H3I8; -.
DR   OMA; CTHIADI; -.
DR   Proteomes; UP000007258; Chromosome 3.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   CDD; cd03221; ABCF_EF-3; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR032781; ABC_tran_Xtn.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR19211:SF14; ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3; 1.
DR   PANTHER; PTHR19211; ATP-BINDING TRANSPORT PROTEIN-RELATED; 1.
DR   Pfam; PF00005; ABC_tran; 2.
DR   Pfam; PF12848; ABC_tran_Xtn; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT   DOMAIN          203..452
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
FT   DOMAIN          512..722
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
SQ   SEQUENCE   724 AA;  82325 MW;  F0FB60C97AB3F810 CRC64;
     MDLAQLQRIL SSHDERVVNI FVSHIPELGL RNIDDCVLEY MLNMLEGQTS SESYLPEEII
     VETMKLYFRE FNVFSGAEEK LNKSTTAICE QMVNEGITKK PSEESSRLAS AVNISRQYEE
     SLKRATMIKS VGKVTAANTN EDWTWEMKRS AAKDMRKKRK DDEKKAMLAE EYEEFLRKRG
     ISSTTAVTKL HHKGEGTNYS TDIRCEAIHI QLGKQVLLDE TDLVLLTGHK YGLIGRNGAG
     KTTLLRALAE RELEGVSPFM QILHVEQEIV AGMETPLEVL LATDVERLQL LREEQELLKQ
     NDTEANARLN DVYARLDAID AHSAEARAAT ILHGLSFTQD MMTSPTKQLS GGWRMRVALA
     RALFVEPDVL LLDEPTNHLD LFAVLWLEQF LKDWQKTLIV VSHSRTFLNN VCSETIHLVG
     HHLHYYTGNY DQFEITRVEQ ERQQKKQHAA QEKHRAHIQA FIDKFRYNAN RAKMAQSRIK
     ALERMEMVAD VVRDPQFAFT FPDPEPVSGS FIELVDCEFG YKPGVSLFKD VNMGIDENSR
     IVLVGANGVG KSTLMNVCTG SLQPRSGTVV RNKKIRIAHF AQHNMESLTP QLSSLEFLRT
     KFPHMEDQQL RAHLGSMGLS GERALQPVYT LSGGQKSRLV LAWITFQKPH LLLLDEPTNH
     LDIDTVNALI EALLTYNGGL LVISHDEYFI TSLCDNIFVC ENNTVRKFDG DFAEYRKHVM
     KIMK
//