ID A4H5Z1_LEIBR Unreviewed; 440 AA.
AC A4H5Z1;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Dehydrogenase-like protein {ECO:0000313|EMBL:CAM37211.1};
GN ORFNames=LBRM_10_0090 {ECO:0000313|EMBL:CAM37211.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM37211.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM37211.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37211.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM37211.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM37211.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|RuleBase:RU000363}.
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DR EMBL; FR798984; CAM37211.1; -; Genomic_DNA.
DR RefSeq; XP_001562781.1; XM_001562731.1.
DR AlphaFoldDB; A4H5Z1; -.
DR STRING; 5660.A4H5Z1; -.
DR GeneID; 5413262; -.
DR KEGG; lbz:LBRM_10_0090; -.
DR VEuPathDB; TriTrypDB:LbrM.10.0090; -.
DR VEuPathDB; TriTrypDB:LBRM2903_100005800; -.
DR InParanoid; A4H5Z1; -.
DR OMA; NPWEGAQ; -.
DR Proteomes; UP000007258; Chromosome 10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43157; PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED; 1.
DR PANTHER; PTHR43157:SF65; PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 440 AA; 48019 MW; 43BD1C33FC264402 CRC64;
MCSPPSLTVR LALPTNGCIV QLISLRKMIH LGNCYIPWLV FTLAELRAVL CQIAFLVAGS
AILDPLCRRG VAGGALLACY TVVMFFFQRR LASGFSVRFS SLRAWRSSPK NFRKTSAFLK
ALKAKKTSAA SVSVAGFGAH PVAVITGGER GIGEEVVDQL LREGLDVILC CPFEAAALRT
IAKLEARTPN SLLRFLKLNL NDEECVRQSA AAVLEMTPRI DVLINNAGLA NPLSYKMNKR
GYEVVLSINF LGHALFTELL LERVMASAPS RIVNVASLMH LNACMPGSCK TALDAMTANC
DPASPHHTHN YSLSKLLLVC YTRDLARRLR GTDTVAAVVH PGVVLTDIYA FAAVFMKVFL
RTVFKFPGEG AEVVLYCTLA DGIRSGSFYA DCTEYDGLLS PLALDDAHNE RLRRVLLRYF
ALDTSKPTGK LLPEVVESML
//
