ID A4HBQ9_LEIBR Unreviewed; 758 AA.
AC A4HBQ9;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 05-APR-2011, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Putative DNA polymerase eta {ECO:0000313|EMBL:CAM38848.2};
GN ORFNames=LBRM_21_0680 {ECO:0000313|EMBL:CAM38848.2};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM38848.2, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM38848.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM38848.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM38848.2, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM38848.2,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; FR798996; CAM38848.2; -; Genomic_DNA.
DR RefSeq; XP_001564777.2; XM_001564727.2.
DR AlphaFoldDB; A4HBQ9; -.
DR STRING; 5660.A4HBQ9; -.
DR GeneID; 5415333; -.
DR KEGG; lbz:LBRM_21_0680; -.
DR VEuPathDB; TriTrypDB:LbrM.21.0680; -.
DR VEuPathDB; TriTrypDB:LBRM2903_210011400; -.
DR InParanoid; A4HBQ9; -.
DR Proteomes; UP000007258; Chromosome 21.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0009059; P:macromolecule biosynthetic process; IEA:UniProt.
DR GO; GO:0034654; P:nucleobase-containing compound biosynthetic process; IEA:UniProt.
DR GO; GO:0006301; P:postreplication repair; IEA:UniProt.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR45873; DNA POLYMERASE ETA; 1.
DR PANTHER; PTHR45873:SF1; DNA POLYMERASE ETA; 1.
DR Pfam; PF00817; IMS; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 4..294
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
SQ SEQUENCE 758 AA; 81712 MW; 17D87DB7D54E205C CRC64;
MRCIAHVDMD CFYAQVEAVR LGLDCRVTPF ALLQWGNFIA VNYPARARGV KRFCLSPDEV
RRELPDVQMS HIATYAVGES EYCYPEDPRI NTHKVSLEPY RHASRQIFAI LRSEPGVMVG
KAGIDEAYVD VTEAARRELA EVRAAAAGAS LDPLVDVMEP STRLIEDRRA EMEAWLCARG
TSLAAVFDEP MRALVRGECG AGLEGSRAFC VGADDPAYAE RCLLLCAASR VVHRLRQRIY
AELHYDCSAG IAHNRVLAKC ISATHKPNQQ TLLLPDRGAS ALFELPLSGL RGFGGKLGAA
VSVVCGGVTE CREAWLVPLA QLYKLDGTHD AGVGADAEED GEGHVDDAYA NCRRDTKASN
AGGGGSSTDA KSGTGLYVFY RVRGFGSDTV ADPVLPRGMR ASKIFHPLCS SWSAAQLWMA
PLAGELWHRF SEYESHYYKE GRSLVVVFRT YVTPEQVRRG QHTRSYRAQA PLPANVRDAT
QIADIGLREF VKLMREVTRE EKGGEWKSGS TTSLLSPHLF TNPTNEVPDA PTGIAAPAND
VSAMPPLRFL ELSIIGLRVR PLPPTEGGNG GTAGGTDGGT SASTQCSLAD MFAALSANAT
ASAGSKGTRT AVVGGGVLRK RHRSGSRDAD VTRGLRQEVV VEIDDGNEDE SVSDDCVDVD
VNFGEAAEGV KSDSFFQRGQ LARPAGASSP PLKRTLKDPF HRTTMTTDIS AAERAHVPTS
AARQVTTVCV EEDDVTVCVP QQGCVSITEV SSEDETRS
//
