ID A4HC81_LEIBR Unreviewed; 676 AA.
AC A4HC81;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Carnitine palmitoyltransferase-like protein {ECO:0000313|EMBL:CAM45074.1};
DE EC=2.3.1.21 {ECO:0000313|EMBL:CAM45074.1};
GN ORFNames=LBRM_22_0300 {ECO:0000313|EMBL:CAM45074.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM45074.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM45074.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM45074.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM45074.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM45074.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
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DR EMBL; FR798997; CAM45074.1; -; Genomic_DNA.
DR RefSeq; XP_001564949.1; XM_001564899.1.
DR AlphaFoldDB; A4HC81; -.
DR STRING; 5660.A4HC81; -.
DR GeneID; 5415515; -.
DR KEGG; lbz:LBRM_22_0300; -.
DR VEuPathDB; TriTrypDB:LbrM.22.0300; -.
DR VEuPathDB; TriTrypDB:LBRM2903_220008200; -.
DR InParanoid; A4HC81; -.
DR OMA; NRWWDKS; -.
DR Proteomes; UP000007258; Chromosome 22.
DR GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 1.10.275.20; Choline/Carnitine o-acyltransferase; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR042572; Carn_acyl_trans_N.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF16; CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000313|EMBL:CAM45074.1};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAM45074.1};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 65..617
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
SQ SEQUENCE 676 AA; 75356 MW; 20543BC455E5847D CRC64;
MRTCLPRWCA CEGTRSAAHG PLYASGNWAA LRTNVGASSR EATVEELLTP SLVPTRHYQR
SLPKLPLPTL HDTLQRYLSA AEPLCTPKQL ANTSAIVASF LKGDGLHIHD ELRRTDTANP
HTSYISSDLF EQMLKERSAL PLRSHSTWLV RPDPEKHDML VRSAYWIWAS VHFYKLYLDN
QLRPEVRYVV DGGFAKRSGF WTTEWFQRSA ALLPDCVSTP FVYNVSLGVV RPLDMSQFDC
LFNSSRVPGV LQDEIKPVGF APYVLVQYRG HQFQISVADA DCVPLSIDEL YAQLRDIVHT
NIAPANTDVS VLTALPRTEW NAARTMLLRN VVNGKSLEVV EESMLVLNLD ADDERDVMVD
PMSPVGVTAK SPSVRAGNRW WDKSLSVSVN RRGDIAVSAE SSWGDGVAVR RYINDVYALS
RAAHSHVLRK DAPATHKLRQ LQWHVPAELV ALAKRVAERV KKDRESLDIA AGVLDIDTIP
TPTVEATVQL AAQLAMFRVQ QQPMNCMQRT DLHYYRRGRS EQFPLATPES TAFLLSMRSS
ERQTQQAACH TALQRYKAEK NAVSRGGTTQ SHLLALRLTA ERFLGRVPDL YSDPAFSLVT
RPALHFELAE AEATYGCGYT LQPFSRHLTC SRTGSTLLYQ VTSPLPSSLY GATSSTTFAE
AFTDACREVA DLLALS
//
