ID A4HCE5_LEIBR Unreviewed; 709 AA.
AC A4HCE5;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=LBRM_22_0840 {ECO:0000313|EMBL:CAM45131.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM45131.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM45131.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM45131.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM45131.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM45131.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the AAA ATPase family. BCS1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007448}.
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DR EMBL; FR798997; CAM45131.1; -; Genomic_DNA.
DR RefSeq; XP_001565003.1; XM_001564953.1.
DR AlphaFoldDB; A4HCE5; -.
DR STRING; 5660.A4HCE5; -.
DR GeneID; 5415569; -.
DR KEGG; lbz:LBRM_22_0840; -.
DR VEuPathDB; TriTrypDB:LbrM.22.0840; -.
DR VEuPathDB; TriTrypDB:LBRM2903_220013800; -.
DR InParanoid; A4HCE5; -.
DR OMA; YTRRHVI; -.
DR Proteomes; UP000007258; Chromosome 22.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23070:SF99; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23070; BCS1 AAA-TYPE ATPASE; 1.
DR Pfam; PF00004; AAA; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT DOMAIN 328..577
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 472..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 634..661
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 483..497
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 709 AA; 77739 MW; C285411E117AD30E CRC64;
MTSMTRISSS VISGNKSHEN DFSLFNGETP AQLRQLGPLI HTTVSAFASA LEYWSPFAPE
WLLLLAPFMV GLVQVVWPTV SAGVSVWRSG VGRRYAFRVL VHEAPLNLYD DVNNLNELMV
NAVLMYVCGT LWRQNPVPES QLRGLQMRTM LMDPYRCYKS NDYDSPFRCA YVESDADEGQ
KLKEETVARL RVAKVPLDAY LPVQVDGIEL CYAEESFHRK GSRDPWTRHK LTLRCANSRD
AGAKLDAFVQ RALEVFAEGA PGKEEDDGAR WFFAYGGESD DKVYFNQYVL RSNKGFDTLF
FPQRDATLTL VDQFAQRRGR FAVEGFPQRL GFLVYGPPGT GRHAFVKALA AYTGRHVVSV
PLSKLRTNQQ LYDIFFVREF QSEEGGSVQK LRMEDVIFLF DDVDAANPVV CARAGSRVVQ
RRAAARLTAR AGLRDAPLTT CVIEMDTSSS RPVVRAEDSA LPLALLMEIM GGGASKDGGG
GSKSEGGSRR RTEKRAAVTA GDAGAGVVGR NLFEINGMLF GENKDRLDLA GLLNVLDGVL
DAPGRMVVMI TEHPEWLDPA LVRPGRFSVR LRLDYMEMEA LVQMLGLYYG DVEHSPRGIR
AGAGAVEADA GSGVGAARAA QCPAVGAAGR AVHRELSEAQ VARVRGAVAA LEEEAEAAAA
REVGTDGSGE RKYCFQVTPC EVEMLCMGQD DLEGFLTQLA RVVRGTEQL
//
