ID A4HF63_LEIBR Unreviewed; 410 AA.
AC A4HF63;
DT 01-MAY-2007, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2007, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=ADP-ribosylation factor-like protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LBRM_26_2110 {ECO:0000313|EMBL:CAM39473.1};
OS Leishmania braziliensis.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC Leishmania braziliensis species complex.
OX NCBI_TaxID=5660 {ECO:0000313|EMBL:CAM39473.1, ECO:0000313|Proteomes:UP000007258};
RN [1] {ECO:0000313|EMBL:CAM39473.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39473.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=17572675; DOI=10.1038/ng2053;
RA Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA Fraser A., Rajandream M.A., Carver T., Norbertczak H., Chillingworth T.,
RA Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Squares R.,
RA Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R., Barrell B., Cruz A.K.,
RA Mottram J.C., Smith D.F., Berriman M.;
RT "Comparative genomic analysis of three Leishmania species that cause
RT diverse human disease.";
RL Nat. Genet. 39:839-847(2007).
RN [2] {ECO:0000313|EMBL:CAM39473.1, ECO:0000313|Proteomes:UP000007258}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/BR/75/M2904 {ECO:0000313|EMBL:CAM39473.1,
RC ECO:0000313|Proteomes:UP000007258};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000256|ARBA:ARBA00004555}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000256|ARBA:ARBA00010290}.
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DR EMBL; FR799001; CAM39473.1; -; Genomic_DNA.
DR RefSeq; XP_001562441.1; XM_001562391.1.
DR AlphaFoldDB; A4HF63; -.
DR STRING; 5660.A4HF63; -.
DR GeneID; 5416563; -.
DR KEGG; lbz:LBRM_26_2110; -.
DR VEuPathDB; TriTrypDB:LbrM.26.2110; -.
DR VEuPathDB; TriTrypDB:LBRM2903_260025900; -.
DR InParanoid; A4HF63; -.
DR OMA; GAMDWLV; -.
DR Proteomes; UP000007258; Chromosome 26.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR PANTHER; PTHR45909; ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR45909:SF1; ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1; 1.
DR Pfam; PF00025; Arf; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51417; ARF; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007258}.
FT REGION 55..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 315..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 410 AA; 44700 MW; 7B886DC60C24BC0E CRC64;
MLHFLTGVYN SLFSTPEYNV LIVGRESAGK STLLEQLKFL YTPATQQREA EAISHLNSQQ
QQQAPLSADR SSSNGDAKAI HERVNTVADS STTSAQQHQQ RKQLLPPGTL LPATAVHLAQ
KDIRPTVGLN YAVVQHSFSP LVVTVTLKKP QLSSQTVASL PLPPKDLLAE QRAHQQAVMA
KAPSDAFTRV VLRDLGGQTA LRDLWEKYYA QSQGIVYVID STLPFRVLRE SPASPLRDHF
TQHELKEVYK QDRELLARLL QHPLLHNVPM LLLSNKTDEV SHISLATLQE ALQLVELAAN
PTFYVLQNSG DGGNPSGVLG SQQRLHGSSS GDSTPLSHLS DAAAPPVGTS PSRYCTRSEE
AQLRVGRSGF GKITMRVVEV SALDGVGVAG AMDWLVAQLL HRARDVDDDA
//
